The association between past Chlamydia pneumoniae infection and markers of chronic inflammation in obese women

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
M KoziołekS Giedrys-Kalemba

Abstract

It has been widely accepted that obesity is associated with chronic, low-grade inflammation that affects the adipose tissue as well as the entire system. The aim of this study was to assess whether past Chlamydia pneumoniae infection influences obesity phenotypes and serum levels of low-grade inflammation markers in obese, healthy premenopausal women. The study was performed on 48 obese and 42 normal-weight women, aged 31.2 +/- 7.2 years. Serum levels of C-reactive protein (CRP), tumor necrosis factor alpha (TNFalpha) and its soluble receptor R2 (sTNF-R2), and interleukin 6 (IL-6) were measured. Body composition was assessed by bioimpendance. Insulin sensitivity was assessed by quantitative insulin sensitivity check index (QUICKI). The seroprevalence of C. pneumoniae infection was 69.1% and was similar in obese and normal-weight women (75.2% and 61.9%, respectively; P = 0.18). Obese women had higher CRP than healthy controls (P < 0.05). IL-6, TNFalpha, and sTNF-R2 showed no significant differences when comparing obese and normal-weight or C. pneumoniae infected and uninfected women. In multivariate regression analysis, fat mass (P < 0.001) and QUICKI (P < 0.01), accounting for 35% of the variance of CRP and C. pneumoniae infect...Continue Reading

References

May 17, 1997·BMJ : British Medical Journal·A LaurilaP Saikku
Dec 31, 1997·Obesity Research·N V DhurandharR L Atkinson
Mar 20, 1998·The Journal of Clinical Endocrinology and Metabolism·S K FriedA S Greenberg
Jan 7, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·H HaunerF Hube
Oct 27, 1999·Metabolism: Clinical and Experimental·C TsigosN Katsilambros
Jun 6, 2000·The Journal of Infectious Diseases·J T Grayston
Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·A KatzM J Quon
Feb 28, 2001·Obesity Research·L RoytblatS Gelman
Jan 10, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·F M van DielenJ W Greve
Jun 22, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A M DartS Kay
Jul 27, 2002·European Journal of Clinical Nutrition·P C Calder, R F Grimble
Apr 12, 2003·Obesity Research·Monica BullóJordi Salas-Salvadó
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Sep 18, 2004·Metabolism: Clinical and Experimental·Magdalena Olszanecka-GlinianowiczAleksander Zurakowski
Sep 29, 2004·Journal of the American Geriatrics Society·Pierluigi BlancLuigi Ferrucci
Jun 16, 2005·Diabetes Research and Clinical Practice·Hye Soon ParkRina Yu
Oct 19, 2006·Metabolism: Clinical and Experimental·Joanna JanowskaMagdalena Olszanecka-Glinianowicz
Jan 18, 2007·Obesity·José-Manuel Fernández-RealWifredo Ricart

❮ Previous
Next ❯

Citations

Dec 19, 2009·Epidemiology and Infection·A RantalaP Saikku
Jan 6, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A Jaworowska, G Bazylak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.