Abstract
To date, the association between the acute pulmonary embolism (PE) and the currently existing cancer-related genomic alterations in patients with non-small cell lung cancer (NSCLC) has been understudied. We reviewed patients with a confirmed histopathological diagnosis of NSCLC who underwent computed tomography pulmonary angiography (CTPA) and molecular tests including ALK, ROS1, EGFR, BRAF V600E as well as PD-L1 during the diagnosis of NSCLC, to explore the association between the genomic alterations and PE. The results showed that, for the patients with positive results of genomic alterations, the proportion of positive ALK (13.6%vs8.5%, P<0.001) and PD-L1 (24.7%vs19.9%, P = 0.001) in PE group were more than those in Non-PE group. The patients with positive ALK and PD-L1 had the most (19.0%) and second most (15.4%) incidence of PE among all the patients being studied. A multivariate Logistic regression analysis showed that the positive ALK [1.685(1.065-2.215)(P<0.001)] and PD-L1[1.798(1.137-2.201)(P<0.001)] were correlated with the occurrence of PE. The positive results of ALK and PD-L1 genomic alterations may indicate an increased risk of pulmonary embolism in patients with NSCLC.
References
Feb 11, 2005·JAMA : the Journal of the American Medical Association·Jeanet W BlomFrits R Rosendaal
Mar 7, 2008·The New England Journal of Medicine·Victor F Tapson
Aug 3, 2013·Blood·Jasmijn F TimpSuzanne C Cannegieter
Dec 3, 2013·Thrombosis Research·Luis Corrales-RodriguezNormand Blais
Jan 31, 2014·Thrombosis and Haemostasis·Yun-Gyoo LeeDae Seog Heo
Mar 29, 2014·Chest·Yuhui ZhangUNKNOWN China Venous Thromboembolism (VTE) Study Group
Dec 17, 2014·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Elif Birtas AtesogluAbdullah Hacıhanefioglu
Jun 24, 2015·Thrombosis Research·Whenhui ChenChen Wang
Sep 10, 2015·BMJ : British Medical Journal·Janneke M T HendriksenKarel G M Moons
Sep 18, 2015·Thrombosis Research·Melina VersoGiancarlo Agnelli
May 3, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Richard LiRaymond Mak
Dec 4, 2016·Clinical Lung Cancer·Alona ZerFrances A Shepherd
Jun 3, 2017·Oncotarget·Wei XiongJinming Liu
Feb 6, 2019·Nature Reviews. Clinical Oncology·D Ross CamidgeKeith M Kerr
Jun 12, 2019·CA: a Cancer Journal for Clinicians·Kimberly D MillerRebecca L Siegel
Oct 15, 2019·Clinical Lung Cancer·Rita ChiariFederico Cappuzzo
Nov 8, 2019·European Heart Journal·Stavros V Konstantinides, Guy Meyer
Nov 28, 2019·The New England Journal of Medicine·Clive KearonUNKNOWN PEGeD Study Investigators
Dec 22, 2019·Thrombosis Research·Feifei DouYuhui Zhang