The association between rs1972820 and the risk of breast cancer in Isfahan population

Journal of Cancer Research and Therapeutics
Narges ZabihiMohammad Fazilati

Abstract

A number of single nucleotide polymorphisms (SNPs) in ERBB4 gene have been linked to increase the risk of breast cancer. However, no study has been dedicated to analyze the significance of microRNA-related SNP rs1972820, located in ERBB4 3'-untranslated region (UTR), in breast tumors. Here, we investigated the frequency and association between rs1972820 and breast cancer. The rs1972820 genotypes in 182 samples were collected from 96 healthy people, and 86 breast cancer patients were determined using tetra-primer amplification refractory mutation system-polymerase chain reaction. The frequency of genotypes was analyzed to find the association between rs1972820 and breast cancer risk. Conditional logistic regression, odds ratios (ORs), the associated 95% confidence intervals (CIs), and Armitage's test were used in this study. In silico analysis suggested that rs1972820 located in the 3'UTR of ERBB4 gene affects the binding affinity of miR-3144-3p a potential oncomiRNA. Statistical analysis showed a significant association between SNP rs1972820 G allele and reduced breast cancer risk, odds ratio = 0.443 (95% CI: 0.196-0.998). rs1972820 SNP allele is significantly associated with the reduced risk of breast cancer and could be consi...Continue Reading

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Citations

Feb 20, 2020·Indian Journal of Clinical Biochemistry : IJCB·Maryam TabatabianParisa Mohamadynejad
Jul 28, 2020·Journal of Cellular Physiology·Farbod BahreiniNima Rezaei
Aug 9, 2019·Indian Journal of Clinical Biochemistry : IJCB·Fariba NabatchianKamran Ghaedi
Nov 7, 2019·Indian Journal of Clinical Biochemistry : IJCB·Leila Assad SamaniMansoureh Azadeh
Nov 7, 2019·Indian Journal of Clinical Biochemistry : IJCB·Maedeh RouigariMansoureh Azadeh

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