The association between self-reported major life events and the presence of uterine fibroids.

Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health
Anissa I VinesDenise A Esserman

Abstract

Uterine fibroids are the most common benign tumors in reproductive-age women. Factors associated with this condition such as psychosocial stress are still being elucidated. This paper explores the association between major life events (MLE) stress and fibroids. Prevalence ratios (PR) and 95% confidence intervals (CI) were used to determine the association between MLE stress (number of events and stress intensity) and fibroids in 556 Black and 373 White women in the Uterine Fibroid Study, 1996-1999. Fibroids were prevalent in 74% and 50% of the Black and White women, respectively. The mean number of MLE reported by each race group was two. Among White women, the PR for those who reported at least one event compared with those with no events were significant after adjusting for age and study identified fibroid risk factors (PR [1 and 2 events], 1.7; 95% CI, 1.2-2.5), (PR [3 events], 1.9; 95% CI, 1.3-2.7), and (PR [4 events], 1.5; 95% CI, 1.0-2.1), respectively. At all levels of stress compared with no events, significant associations with fibroids were found among White women. For Black women, the PR for fibroids was only significant in the high stress group compared with those without an experienced event, after adjusting for fi...Continue Reading

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Citations

Jul 23, 2014·BioMed Research International·Danuta PlewkaAndrzej Plewka
Jan 9, 2016·Clinical Obstetrics and Gynecology·Lauren A Wise, Shannon K Laughlin-Tommaso
Jan 9, 2013·American Journal of Obstetrics and Gynecology·Lauren A WiseLynn Rosenberg
Dec 17, 2014·American Journal of Obstetrics and Gynecology·Lauren A WiseLynn Rosenberg
May 25, 2016·Current Obstetrics and Gynecology Reports·Nick Dalton-Brewer
Oct 30, 2016·Explore : the Journal of Science and Healing·Elliott G RichardsShannon K Laughlin-Tommaso
Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dana DvorskáJozef Višňovský
Dec 15, 2010·Epidemiology·Donna Baird, Lauren A Wise
Jul 18, 2019·Genetic Testing and Molecular Biomarkers·Mei-Rong LiangOu-Ping Huang
Aug 28, 2019·Stress and Health : Journal of the International Society for the Investigation of Stress·Hao QinLuo Xu
Sep 16, 2016·Journal of Women's Health·Lulu SongYoujie Wang
Oct 9, 2018·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·Lisa S CallegariCarolyn Gardella
Jun 9, 2021·Journal of Women's Health·Kedra WallaceErica Marsh
Jul 3, 2021·The Journal of Obstetrics and Gynaecology Research·Bing-Jie WuFei Zhong

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