The association between serum iron status and risk of asthma: a 2-sample Mendelian randomization study in descendants of Europeans

The American Journal of Clinical Nutrition
Lulu HuangXiaobo Yang

Abstract

Observational studies present conflicting results about a possible association of iron status with asthma risk, pointing to potential modifiable targets for prevention. The aim of this study was to use Mendelian randomization (MR) to estimate associations between iron status and asthma risk. We used the Genetics of Iron Status consortium to identify genetic variants that could be used as instrumental variables for the effect of systemic iron status. The following sets of instruments were used: a conservative set (instruments restricted to variants with concordant relations to 4 iron status biomarkers) and a liberal set (instruments selected using variants associated with at least 1 of 4 iron status biomarkers). Associations of these genetic variants with asthma risk were estimated in data from the Trans-National Asthma Genetics Consortium (TAGC) and the GABRIEL consortium (A Multidisciplinary Study to Identify the Genetic and Environmental Causes of Asthma in the European Community). Data on the association of genetic variants with iron status and with asthma were combined to assess the influence of iron status on asthma risk. In the conservative approach, the MR OR of asthma was 1.00 (95% CI: 0.91, 1.10) per SD increase in iro...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Aug 15, 2000·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·H VuralO Akyol
Jun 7, 2006·Epidemiology·Miguel A Hernán, James M Robins
Sep 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Jay B Wish
Sep 22, 2007·Statistics in Medicine·Debbie A LawlorGeorge Davey Smith
Jul 9, 2008·Trends in Genetics : TIG·Tracey A Rouault, Wing Hang Tong
Mar 27, 2009·Pediatric Hematology and Oncology·Ellen Butensky JamesChristine Miaskowski
Mar 23, 2010·Expert Review of Respiratory Medicine·Theresa W Guilbert, Loren C Denlinger
Apr 27, 2010·Nature Genetics·UNKNOWN Tobacco and Genetics Consortium
Sep 4, 2010·International Journal of Epidemiology·Brandon L PierceTyler J Vanderweele
Sep 8, 2010·Lancet·William W BusseJames E Gern
Sep 24, 2010·The New England Journal of Medicine·Miriam F MoffattUNKNOWN GABRIEL Consortium
Sep 14, 2011·Clinical and Experimental Immunology·H MaaziA J M van Oosterhout
Sep 3, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andrew J GhioGökhan M Mutlu
Oct 8, 2013·Nature Genetics·Cristen J WillerUNKNOWN Global Lipids Genetics Consortium
Oct 12, 2013·Genetic Epidemiology·Stephen BurgessSimon G Thompson
Oct 30, 2014·Nature Communications·Beben BenyaminJohn B Whitfield
Feb 18, 2015·Epidemiology·Ulrike GehringBert Brunekreef
Feb 18, 2015·PloS One·Emily P BrighamElizabeth C Matsui
Feb 19, 2015·American Journal of Respiratory and Critical Care Medicine·Amisha V BarochiaStewart J Levine
Mar 17, 2015·European Journal of Epidemiology·Stephen BurgessUNKNOWN EPIC- InterAct Consortium
Apr 25, 2015·Nature Reviews. Immunology·Valerie JuliaDavid Dombrowicz
May 8, 2015·Statistics in Medicine·Fabiola Del Greco MJohn R Thompson
Jun 8, 2015·International Journal of Epidemiology·Jack BowdenStephen Burgess
Jul 22, 2015·Nature Reviews. Cardiology·Stephan von HaehlingStefan D Anker
Sep 24, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L ZhaoF Wang
Sep 7, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Andrew J Ghio
May 21, 2017·European Journal of Epidemiology·Stephen Burgess, Simon G Thompson
Jun 2, 2017·Nature Reviews. Cardiology·Michael V HolmesGeorge Davey Smith
Sep 26, 2017·Current Medical Research and Opinion·Xinming SuJian Kang
Dec 24, 2017·Lancet·Alberto PapiHelen K Reddel
Dec 5, 2018·Respiratory Medicine·Song MaoWenjing Shi

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