The Association between Serum Uric Acid and Bone Mineral Density in Older Adults

International Journal of Endocrinology
Xiaocong YaoZhongxin Zhu

Abstract

Uric acid has been found to be potentially protective in bone metabolism. We investigated the relationship between serum uric acid (sUA) and lumbar bone mineral density (BMD) among 4156 participants aged 60 years and over from the National Health and Nutrition Examination Survey (NHANES). To estimate the association between sUA and lumbar BMD, multivariate logistic regression analyses were conducted. Fitted smoothing curves and generalized additive models were also performed. We found sUA positively correlated with lumbar BMD after adjusting for other confounders. On subgroup analyses, stratified by sex and race/ethnicity, the positive correlation of sUA with lumbar BMD remained in both men and women, as well as in whites and Mexican Americans, but not in blacks. In blacks, the association of sUA with lumbar BMD was an inverted U-shaped curve (inflection point: 7.5 mg/dL). Our study revealed a positive relationship between sUA and lumbar BMD among most old adults. This association followed an inverted U-shaped curve among blacks.

References

Jan 15, 2013·Current Rheumatology Reports·Jasvinder A Singh
May 7, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S H AhnG S Kim
Dec 11, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Dihua ZhangKhashayar Sakhaee
Dec 11, 2014·Metabolism: Clinical and Experimental·Tapan MehtaDiana Jalal
Dec 17, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nicola DalbethTony R Merriman
Dec 24, 2014·Advances in Therapy·Fernando Perez-RuizTomas Bardin
Nov 22, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A XiongZ Zhang
Dec 20, 2015·The Journal of Clinical Endocrinology and Metabolism·Taulant MukaFernando Rivadeneira
Oct 12, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M PirroT Merriman
Aug 1, 2018·Nutrients·Claudio TanaTiziana Meschi
Jun 14, 2019·Journal of Nutrition and Metabolism·Masaru Kubota
Jul 5, 2019·International Journal of Environmental Research and Public Health·Peizhi WangMythily Subramaniam
Jul 12, 2019·European Journal of Clinical Investigation·Young Ho Lee, Gwan Gyu Song
Sep 10, 2019·International Journal of Endocrinology and Metabolism·Mansour BabaeiSeyed Reza Hosseini
Dec 19, 2019·International Journal of Molecular Sciences·Gloria BonaccorsiCarlo Cervellati

❮ Previous
Next ❯

Citations

Mar 7, 2021·Biomolecules·Wei-Zheng Zhang
Apr 20, 2021·Frontiers in Endocrinology·Wisam Nabeel IbrahimMarawan Abdelhamid Abu-Madi
Jun 10, 2021·Scientific Reports·Jung Woo LeeHyo Geun Choi
Jun 11, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Tomaz KocjanBarbara Ostanek

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.