The association between serum vitamin d level and cognitive function in older adults: Cooper Center Longitudinal Study

Preventive Medicine
Andjelka PavlovicLaura F DeFina

Abstract

Low blood level of vitamin D and low physical activity have been linked to the development of cognitive impairment in older adults. The purpose of the present study was to examine the relationship between serum vitamin D and cognition as measured via the Montreal Cognitive Assessment (MoCA) in a healthy, older population. The study sample consisted of 4358 patients from the Cooper Clinic in Dallas, TX. All participants underwent a maximal graded exercise test to determine cardiorespiratory fitness (CRF). Cognitive impairment was defined as a MoCA score <25. Low vitamin D status was defined as serum 25-hydroxyvitamin D <30 ng/mL. Multivariable logistic regression analysis was employed to evaluate the association between vitamin D blood level and MoCA score. A low MoCA score was directly associated with higher age (OR: 1.75, 95% CI: 1.53, 1.99), and inversely associated with female sex (OR: 0.63, 95% CI: 0.51, 0.77), and years of education (OR: 0.87, 95% CI: 0.84, 0.91). When controlling for significant predictors (age, sex, and education), the low vitamin D group had a significantly greater likelihood of having a low MoCA score (OR: 1.26, 95% CI: 1.04, 1.51). The vitamin D effect remained significant when CRF was added to the mo...Continue Reading

Citations

Mar 12, 2019·Journal of the American Geriatrics Society·Erline E Martinez-MillerLaura F DeFina
Jan 26, 2021·Geriatrics & Gerontology International·Ryota SakuraiUNKNOWN Takashimadaira Study Group
Aug 29, 2021·Journal of Aging and Physical Activity·Tal GafniLaura F DeFina
Jan 3, 2020·Journal of Strength and Conditioning Research·Stephen W FarrellWilliam L Haskell

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