The Association Between Sleep Disorders and the Risk of Colorectal Cancer in Patients: A Population-based Nested Case-Control Study

In Vivo
Chia-Ling LinWu-Chien Chien

Abstract

To investigate the risk of colorectal cancer in patients with sleep disorders. We identified 7,355 participants with colorectal cancer between January 1, 2000, and December 31, 2013, from the Longitudinal Health Insurance Database 2005 of the Taiwan National Health Insurance Research Database; 29,420 controls were also identified from the same database based on frequency matching on age, sex, and index date of the cases. Diagnoses of sleep disorders by International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) in the cases and controls prior to the index date were assessed. The risk of colorectal cancer in patients with sleep disorders was estimated with multivariate logistic regression analyses. The mean age of the 36,775 patients was 63.05 years, and 56% of them were males. The risk of colorectal cancer was higher in patients with sleep disorders compared to those without [adjusted odds ratio (OR)=1.29, 95% confidence interval (CI)=1.13-1.47]. The risk of colorectal cancer was higher in patients having sleep disorders with depression compared to those without the condition (adjusted OR=5.69, 95% CI=4.01-6.98). The risk of colorectal cancer in patients with sleep disorders was found to be signif...Continue Reading

Citations

Jul 6, 2019·Journal of Cellular Physiology·Mohammad Mirza-Aghazadeh-AttariBahman Yousefi
Feb 20, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Isaac AlmendrosDavid Gozal
Jul 13, 2019·International Journal of Environmental Research and Public Health·Hyeyun KimYeong In Kim
Oct 23, 2019·BioMed Research International·Hucong WuGuoqiang Zhu
Oct 24, 2020·Current Genomics·Anna BrzeckaGjumrakch Aliev
Mar 30, 2021·OncoTargets and Therapy·Sangiliyandi GurunathanJin-Hoi Kim
Nov 16, 2021·Oncology Reports·Ronald Neil KostoffDemetrios A Spandidos

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