The association between the serum C-peptide level and bone mineral density

PloS One
Ying LiYasuto Sato

Abstract

Although serum C-peptide was previously considered biologically inactive, a growing number of recent studies have shown that it is an active peptide with important physiologic functions. The present study aimed to investigate the association of serum C-peptide level with bone mineral density (BMD) in residents of the United States. The study included 6,625 participants aged 12-85 years. Total and regional BMD were measured using dual-energy X-ray absorptiometry. Stratified multiple linear regression analysis was performed to determine the association of the serum C-peptide level with BMD. Three regression models were produced for each stratum. All models were adjusted for ethnicity, height, weight, education level, physical activity, smoking status, alcohol use, triglycerides and creatinine level, and models 2 and 3 were further adjusted for the fasting plasma glucose (FPG) and alkaline phosphatase (ALP) levels, respectively. Sex-specific results showed a significant association between the serum C-peptide level and total BMD in both sexes. Stratified analyses based on age and body mass index showed that serum C-peptide levels were significantly negatively associated with most regional BMD, and most of these associations remain...Continue Reading

References

Nov 1, 1992·Clinical Endocrinology·J E CompstonK T Khaw
Jan 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R LindsayS Himmelstein
Sep 1, 1991·Calcified Tissue International·R Bouillon
Dec 1, 1990·Journal of the American Geriatrics Society·G PaciniG Crepaldi
Feb 1, 1989·Australian and New Zealand Journal of Medicine·E Seeman, T Allen
Dec 1, 1989·Diabetes·B GumbinerR I Fink
Mar 15, 1995·Annals of Internal Medicine·P L van DaeleH A Pols
Mar 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·S J GallacherA C MacCuish
May 1, 1993·American Journal of Epidemiology·C CooperL J Melton
Sep 1, 1997·The Journal of Clinical Endocrinology and Metabolism·R OkazakiT Matsumoto
Apr 4, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·B AbrahamsenH Beck-Nielsen
Mar 30, 2001·The Journal of Biological Chemistry·C S AdamsI M Shapiro
Nov 22, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M EspallarguesA Granados
Dec 14, 2001·Biochemical and Biophysical Research Communications·M RomanelloP D'Andrea
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Sep 12, 2002·Cellular and Molecular Life Sciences : CMLS·J ShafqatH Jörnvall
May 29, 2003·JAMA : the Journal of the American Medical Association·Sylvia Wassertheil-SmollerUNKNOWN WHI Investigators
Oct 11, 2005·American Journal of Physiology. Endocrinology and Metabolism·Kathryn M ThrailkillJohn L Fowlkes
Feb 15, 2007·The Journal of Clinical Endocrinology and Metabolism·Lan-Juan ZhaoHong-Wen Deng
Jul 10, 2010·BMJ : British Medical Journal·Beatrice J EdwardsJane A Cauley
Oct 19, 2010·Diabetes Research and Clinical Practice·Yijun ZhouHongwu Yang
Mar 28, 2012·European Journal of Epidemiology·Lili MaFernando Rivadeneira
May 28, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M BethelL D Carbone

❮ Previous
Next ❯

Citations

Jun 15, 2016·Medicinal Research Reviews·Zaid AmsoMargaret A Brimble
Jan 27, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T MontalciniC Gazzaruso
Apr 5, 2017·Endocrine·Arturo PujiaTiziana Montalcini
Apr 13, 2017·Journal of Endocrinological Investigation·Y FerroT Montalcini
Nov 28, 2017·Expert Opinion on Pharmacotherapy·Cy W Fixen, Danielle R Fixen

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

Hologic Discovery
SAS

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Related Papers

Diabetic Medicine : a Journal of the British Diabetic Association
B AbrahamsenH Beck-Nielsen
Diabetic Medicine : a Journal of the British Diabetic Association
S Arnold-LarsenC Kühl
© 2021 Meta ULC. All rights reserved