The Association Between Three Genetic Variants in MicroRNAs (Rs11614913, Rs2910164, Rs3746444) and Prostate Cancer Risk

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Yuanyuan MiTakahiro Yasui

Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules which play a significant role in transcriptional and translational regulation. Published data on the association between the miRNA SNPs and prostate cancer (PCa) risk are somewhat inconclusive. We performed a meta-analysis of all available studies including 2,227 patients and 2,331 control subjects to evaluate the impact of three common genetic variants of microRNAs in prostate cancer risk. Odds ratios (ORs) with 95% confidence intervals (CIs) were utilized to investigate the strength of the association. For miR-499 polymorphism, a significant association was observed between the rs3746444 A>G polymorphism and PCa risk in heterozygote comparison and dominant genetic model, in particular in Asian population subgroup. For miR-146a polymorphism, the rs2910164 CC genotype was associated with decreased PCa risk in Asian population in homozygote comparison. In addition, rs2910164 CC genotype had a weekly higher percentage value in subgroup of Gleason score < 7. Similar results were also indicated in localized prostate cancer in subgroup analysis by tumor stage. For miR-196a2 polymorphism, no association was observed between this variant and PCa risk in the overall group...Continue Reading

Citations

Sep 1, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Alshaymaa A IbrahimTamer A Abdel Hamid
May 1, 2019·Journal of Cellular Biochemistry·Feng DaiYu Bai
Jul 2, 2019·Journal of Cellular Biochemistry·Lijie ZhuLi Zuo
Mar 14, 2019·International Urology and Nephrology·Ramin Nouri, Saeid Ghorbian
Jan 28, 2020·European Journal of Clinical Investigation·Jae Hyon ParkGabriele Gamerith
Dec 10, 2020·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Neda K DezfuliEsmaeil Mortaz

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