The association between total and positive lymph node counts, and disease progression in clinically localized prostate cancer

The Journal of Urology
Timothy A MastersonPeter T Scardino

Abstract

We examined the association between the number of LNs removed, the number of positive LNs and disease progression in patients undergoing pelvic lymph node dissection and radical retropubic prostatectomy for clinically localized prostate cancer. We analyzed 5,038 consecutive patients who underwent radical retropubic prostatectomy between 1983 and 2003. Clinicopathological parameters, including the administration of neoadjuvant hormonal therapy, preoperative prostate specific antigen, specimen Gleason score, surgeon and pathological stage, were collected prospectively in our prostate cancer database. We excluded men treated with radiation or chemotherapy before surgery. BCR was defined as 2 postoperative prostate specific antigen increases greater than 0.2 ng/ml. Cox models were used to determine whether the number of nodes removed or the number of positive nodes predicted freedom from BCR after adjustment for prognostic covariates. The 4,611 eligible patients had a median of 9 LNs (IQR 5 to 13) removed. Positive nodes were found in 175 patients (3.8%). Overall the number of LNs removed did not predict freedom from BCR (HR per additional 10 nodes removed 1.02, 95% CI 0.92 to 1.13, p = 0.7). Results were similar in patients receiv...Continue Reading

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Citations

Mar 17, 2007·World Journal of Urology·Nivedita Bhatta DharUrs E Studer
Mar 29, 2008·World Journal of Urology·Fiona C Burkhard, Urs E Studer
May 11, 2011·International Journal of Clinical Oncology·Jun Miki, Shin Egawa
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