The association between vitamin D and inflammation with the 6-minute walk and frailty in patients with heart failure

Journal of the American Geriatrics Society
Rebecca BoxerAnne Kenny

Abstract

To identify relationships between anabolic hormones, inflammatory markers, and physical function. Cross-sectional. Outpatient university heart failure program in Connecticut. Sixty patients with an ejection fraction of 40% or less. The 6-minute walk distance and frailty phenotype were measured. The relationship between physical measures of hormones and inflammatory mediators were examined. Linear and ordinal logistic regression analyses were performed for the physical measures. Forty-three men (mean age 77 +/- 9) and 17 women (mean age 78 +/- 12) participated. Longer 6-minute walk distance was correlated with higher 25-hydroxyvitamin D (25OHD) level, and a shorter walk was correlated with higher cortisol: dehydroepiandrosterone sulphate (DHEAS) ratio, high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL6), and intact parathyroid hormone (PTH) (all P<.05). Percentage of free testosterone, DHEAS alone, and N-terminal pro-brain natriuretic peptide (NTpro-BNP) did not correlate with 6-minute walk distance. Higher frailty phenotype score (more frail) was correlated with higher high-sensitivity CRP, higher IL6, and lower 25OHD levels (all P<.05). Linear regression with the 6-minute walk distance as the dependent variable an...Continue Reading

References

May 1, 1992·Circulation·H DrexlerH Just
Feb 1, 1988·International Journal of Cardiology·D P LipkinP A Poole-Wilson
Jul 1, 1986·Journal of Applied Physiology·E F CoyleJ L Ivy
Feb 1, 1993·Journal of Clinical Epidemiology·R A WashburnC A Janney
Feb 1, 1993·Aging : Clinical and Experimental Research·J Cornoni-HuntleyP A Scherr
Jul 1, 1997·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·H J CohenM S Currie
Oct 8, 1997·The American Journal of Medicine·E ShaneD J McMahon
Nov 22, 1997·Hypertension·E Kristal-BonehJ Ribak
Dec 31, 1997·Journal of the American College of Cardiology·D HarringtonA J Coats
Jan 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C W ParkB K Bang
Feb 13, 1999·Journal of the American Geriatrics Society·M MowéT Bøhmer
Nov 30, 1999·Journal of the American College of Cardiology·D ManciniA Weinberg
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M PfeiferC Hansen
Oct 18, 2000·Annals of Internal Medicine·D P Kotler
Feb 24, 2001·Aging : Clinical and Experimental Research·H J VerhaarS A Duursma
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A B NewmanUNKNOWN Cardiovascular Health Study Research Group
May 15, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J K DhesiT J Allain
May 30, 2002·European Journal of Heart Failure·J L Alonso-MartínezC González-Arencibia
Aug 7, 2002·International Journal of Cardiology·Stefan D Anker, Rakesh Sharma
Jan 10, 2003·Journal of Cellular Biochemistry·Yan Chun Li
Feb 1, 2003·International Journal of Cardiology·Panagiotis E KontoleonJohn N Nanas
Feb 6, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Heike A BischoffMartin Conzelmann
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Anne R CappolaLinda P Fried
Aug 16, 2003·Journal of the American Geriatrics Society·Nancy K LathamIan R Reid
Aug 29, 2003·The American Journal of Cardiology·Matteo CesariMarco Pahor
Sep 6, 2003·Journal of the American College of Cardiology·Douglas L Mann, Michael B Reid
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Greet Van den BergheRoger Bouillon
Mar 17, 2004·Heart·P J PughK S Channer
Jul 22, 2004·JAMA : the Journal of the American Medical Association·Véronique L RogerSteven J Jacobsen
Aug 24, 2004·The American Journal of Clinical Nutrition·Heike A Bischoff-FerrariBess Dawson-Hughes
Sep 16, 2004·American Journal of Physiology. Endocrinology and Metabolism·Wei XiangYan Chun Li
Oct 8, 2004·Journal of Cardiac Failure·Frederick A MasoudiUNKNOWN Cardiovascular Outcomes Research Consortium
Oct 23, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·P E Norman, J T Powell
Dec 23, 2004·The Journal of Clinical Endocrinology and Metabolism·H H ChoiS Bhasin

❮ Previous
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Citations

Feb 18, 2011·Current Heart Failure Reports·Miles D Witham
Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Milos Cekic, Donald G Stein
Jun 14, 2012·European Journal of Clinical Nutrition·E SmitR E Andersen
Apr 25, 2012·Rejuvenation Research·Paola FortiMarco Zoli
Jul 19, 2011·International Journal of Epidemiology·Michael P GardnerUNKNOWN Halcyon study team
Apr 28, 2011·AIDS·Jean-Paul ViardUNKNOWN EuroSIDA Study Group
Apr 28, 2012·PloS One·Elena D ToffanelloEnzo Manzato
Oct 29, 2013·Heart, Lung & Circulation·Wei Ren ChenYuan Sha
Feb 5, 2014·The Journal of Infectious Diseases·Leah ShepherdUNKNOWN EuroSIDA in EuroCOORD
Apr 16, 2014·Current Heart Failure Reports·Izabella UchmanowiczKrystyna Łoboz-Grudzień
Jun 22, 2013·BMC Geriatrics·Kim BouillonG David Batty
Sep 29, 2011·Current Cardiovascular Risk Reports·Jonathan Afilalo
Mar 21, 2009·The Journal of Nutrition, Health & Aging·S Conroy
Sep 24, 2015·Scandinavian Cardiovascular Journal : SCJ·Erdal BelenMustafa Azmi Sungur
Oct 16, 2013·Journal of Cardiac Failure·Anna J Meredith, Bruce M McManus
Sep 24, 2013·La Presse médicale·Thierry Thomas, Karine Briot
Jun 20, 2012·Journal of the Academy of Nutrition and Dietetics·Nicholas A McKeagPascal P McKeown
Sep 20, 2011·Heart Failure Clinics·Ileana L PiñaRebecca Boxer
Jul 8, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Donald G Stein, Milos M Cekic
Mar 25, 2011·Heart & Lung : the Journal of Critical Care·Colleen DelaneyRichard Fortinsky
Nov 30, 2010·International Journal of Cardiology·Varvara AgapitouSerafim Nanas
Jul 14, 2009·Medicina clínica·Pedro Abizanda SolerJuan José Baztán Cortés
May 30, 2009·Pharmacotherapy·Carrie W NemerovskiBarry E Bleske
Mar 31, 2010·Molecular Nutrition & Food Research·Stefan PilzWinfried März
Apr 5, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Violet LagariSilvina Levis
Jun 10, 2010·Journal of Internal Medicine·E R Wilhelm-LeenG M Chertow
Aug 21, 2010·International Journal of Andrology·M D L O'ConnellF C W Wu
May 17, 2012·Congestive Heart Failure·Christina DiCarloRebecca Boxer
Mar 6, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Cédric AnnweilerOlivier Beauchet
May 6, 2011·European Journal of Heart Failure·Licette C Y LiuRudolf A de Boer
Jun 6, 2014·Journal of the American Geriatrics Society·Jonathan Afilalo
Aug 19, 2015·Maturitas·Yuen Ye Wong, Leon Flicker
May 26, 2009·The American Journal of Cardiology·Jonathan AfilaloHoward Bergman

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