The association of (18)F-FDG PET and glucose metabolism biomarkers GLUT1 and HK2 in p16 positive and negative head and neck squamous cell carcinomas

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Andrew M BaschnagelGeorge D Wilson

Abstract

To investigate the relationship between FDG-PET maximum standard uptake value (SUVmax), p16, EGFR, GLUT1 and HK2 expression in head and neck squamous cell carcinomas (HNSCC). Immunohistochemical staining of p16, EGFR, GLUT1 and HK2 was performed on primary tumor tissue from 97 locally advanced HNSCC patients treated with definitive chemoradiation. SUVmax along with p16, EGFR, GLUT1 and HK2 expression were analyzed for associations including local control, locoregional control and disease free survival. Pretreatment SUVmax in primary tumors did not differ when stratified by p16, EGFR or GLUT1 expression but SUVmax was significantly higher in HK2 expressing tumors (p=0.021) and in tumors with higher T-stage (p=0.022). GLUT1 expression was significantly higher in p16 negative (p<0.001) and EGFR positive tumors (p<0.01). HK2 expressing tumors were associated with EGFR positive tumors (p=0.022) but not with p16 or GLUT1 expression. EGFR positive, p16 negative and high GLUT1 expressing tumors were associated with worse local control and disease free survival on univariate analyses. After adjusting for patient and treatment characteristics p16 status was the only factor that predicted for outcome on multivariate analysis. High GLUT1 e...Continue Reading

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Citations

Nov 21, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·B SamamaN Boehm
Feb 7, 2020·Biology·Stephanie A StalderGrégoire B Morand
Aug 19, 2017·Cancer Metastasis Reviews·Masashi YamamotoTakashi Nakagawa
Jul 28, 2021·Scientific Reports·Nan-Chin LinMichael Y C Chen
Aug 28, 2021·Cancers·Monika Pliszka, Leszek Szablewski

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