The association of adverse outcomes in the mother with disease progression in offspring in families with clusters of hepatitis B virus infection and unfavorable prognoses in Northwest China

Medicine
Yuan YangYingren Zhao

Abstract

To investigate the transmission routes of hepatitis B virus (HBV) in families with clusters of infection and unfavorable prognoses and to analyze the prevalence of liver cirrhosis (LC) or hepatocellular carcinoma (HCC) in the offspring of these families.Families with clusters of HBV infection and unfavorable prognoses were enrolled in the study, and general information and serum samples were collected. The prevalence of LC or HCC was compared in offspring of different genders whose parents were diagnosed with LC or HCC.This analysis comprised 102 probands with 51 siblings, 15 parents, 284 children, and 74 spouses. Interestingly, 88.2% of the siblings and 76.8% of the children of these probands were positive for hepatitis B surface antigen (HBsAg), compared with only 9.5% of the spouses (P < .001). There were 266 nuclear families from 102 clustering families. The prevalence of LC or HCC in sons (44.8%) was higher than that in daughters (8.2%; P < .05) in families with mothers with LC or HCC, but there was no difference in families with fathers with LC or HCC. Moreover, the prevalence of LC or HCC in sons from families with mothers with LC or HCC (44.8%) was higher than in the families with fathers with LC or HCC (21.0%, P = .016...Continue Reading

References

Mar 26, 2003·European Journal of Gastroenterology & Hepatology·Serpil ErolMehmet A Tasyaran
Apr 8, 2003·World Journal of Gastroenterology : WJG·Jian-Min HuangJie-Wen Qiu
Jan 8, 2005·World Journal of Gastroenterology : WJG·Tumay DoganciLevent Doganci
Nov 4, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chih-Lin LinDing-Shinn Chen
Jul 18, 2006·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kunio Takegoshi, Wei Zhang
May 23, 2007·Journal of Medical Virology·Hitoshi TajiriMasashi Mizokami
Mar 6, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Haruki KomatsuTomoo Fujisawa
Mar 5, 2013·Journal of Child Health Care : for Professionals Working with Children in the Hospital and Community·Nafiye UrganciSeda Geylani Gulec
Jun 12, 2013·Seminars in Liver Disease·Francesca GuerrieriMassimo Levrero
May 13, 2015·Journal of Hepatology·Suraj SharmaHarry L A Janssen
Oct 6, 2016·Nature Communications·Ling-Hao ZhaoHong-Yang Wang
Aug 22, 2017·Trends in Microbiology·Kuen-Nan TsaiJing-Hsiung James Ou
Oct 5, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Nader N Massarweh, Hashem B El-Serag
Oct 25, 2017·Hepatology International·Yi-Fen Shih, Chun-Jen Liu
Nov 21, 2017·The Journal of Infectious Diseases·Huey-Ling ChenMei-Hwei Chang
Feb 11, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Shan ShanJidong Jia

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy
blood collection
enzyme-linked immunosorbent assay

Software Mentioned

Info
SPSS
Epi

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved