The association of airway hyperresponsiveness and tuberculin responses

Allergy
A-S Jang, M-H Son

Abstract

The balance between the two subsets of T cell is pivotal for allergic sensitization. We conducted a cross-sectional study of 486 children vaccinated with bacillus Calmette-Guérin (BCG), aged 10-13 years, to evaluate whether tuberculin responses may contribute to airway hyperresponsiveness (AHR). Tuberculin skin test, allergic skin test, and methacholine challenge test were done. The methacholine concentration causing a 20% fall (PC20) in forced expiratory volume in 1 second (FEV1) was used as a threshold of AHR. Atopy was defined as a reaction showing a mean wheal size of > or = 3 mm to one or more allergens on skin prick test (SPT). Two tuberculin units of polysorbate-stabilized purified protein derivatives (PPD) were injected intradermally into the volar surface of the forearm. Reactions were read at 48-72 h as the transverse diameter in millimeters of induration. Of the children in the study, 12.3% (60/486) had PPD induration; 7.8% (38/486) of children had PPD induration of greater than 10 mm. The PPD induration size was 10.5 +/- 1.03 mm (confidence interval (CI) 7.19-12.33) in atopic children and 11.2 +/- 0.76 mm (CI 7.89-13.1) in nonatopic children. The differences of PPD induration diameter between the two groups were not...Continue Reading

References

Oct 1, 1975·The Journal of Allergy and Clinical Immunology·H ChaiR G Townley
Jun 1, 1984·Environmental Health Perspectives·J J O'Neil, J A Raub
Jan 1, 1994·Dermatology : International Journal for Clinical and Investigative Dermatology·M Lacour
Mar 1, 1995·The European Respiratory Journal·M I AsherA W Stewart
Jan 19, 1995·The New England Journal of Medicine·F D MartinezW J Morgan
Jun 1, 1994·The Journal of Allergy and Clinical Immunology·V P KurupR L Coffman
Oct 19, 1996·BMJ : British Medical Journal·S O ShaheenA Goudiaby
Apr 4, 1998·The Journal of Experimental Medicine·F SallustoA Lanzavecchia
May 1, 1997·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·P G HoltB Björkstén
Aug 2, 2000·Allergy·M YilmazS G Kendirli

❮ Previous
Next ❯

Citations

Apr 24, 2007·Current Allergy and Asthma Reports·Charles C ObiharaNulda Beyers
Mar 22, 2002·Allergy·C Grüber, K P Paul
Apr 28, 2005·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Gilles MartignonIsabella Annesi-Maesano
Nov 18, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P BagerT Westergaard
Jun 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P M Matricardi, M Yazdanbakhsh
Feb 13, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ahmet SoysalMustafa Bakir
Nov 16, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Charles C ObiharaJan L L Kimpen
Nov 22, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y MiyakeY Ohya
Dec 24, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Carsten FlohrUNKNOWN ISAAC Phase Two Study Group
Jul 19, 2003·International Journal of Medical Microbiology : IJMM·Claudia Trujillo, Klaus J Erb
Jul 22, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Andrea T BorchersM Eric Gershwin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.