PMID: 7334219Dec 1, 1981Paper

The association of an HLA 'asthma-associated' haplotype and immediate hypersensitivity in familial asthma

Journal of Immunogenetics
R E BradyD M Malish

Abstract

Fifty-seven members from ten families in which one parent and at least one child have asthma were studied with dilutional skin tests and RAST to grass pollens after determination of HLA haplotypes. We found no direct evidence for linkage of a hypothetical asthma locus with HLA or for a significant association of asthma with HLA haplotypes. Linkage between the HLA loci and a gene or genes which allow for the expression of clinical asthma could neither be proven nor disproven due to the small sample size. All of the asthmatic children had positive dilutional skin tests and RAST, suggesting that atopic asthma may be genetically controlled by the HLA chromosome (chromosome 6). Nonetheless, determination of the histocompatibility antigens can increase the value of predictive risk analysis for asthma. Such a determination may be important in the early identification of a child born to a family with atopic asthma.

References

Feb 22, 1975·Lancet·S J GeertsJ J van Rood
Jun 1, 1976·The Journal of Pediatrics·J G Schaller, G S Omenn
Apr 22, 1977·Science·V A McKusick, F H Ruddle
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·D G MarshK Ishizaka
Aug 1, 1971·Acta Allergologica·M L Edfors-Lubs
Jan 1, 1974·The Medical Clinics of North America·C Cohen
Jun 21, 1974·Science·M N BlumenthalH Noreen
Sep 1, 1974·The Journal of Allergy and Clinical Immunology·D R Hoffman, Z H Haddad
May 1, 1980·The Journal of Allergy and Clinical Immunology·D G MarshW B Bias

❮ Previous
Next ❯

Citations

Apr 1, 1990·Tissue Antigens·L R Caraballo, M Hernandez
Jul 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W O CooksonA W Musk
May 3, 2000·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·A ToríoM R Alvarez-López
Oct 1, 1988·Tissue Antigens·W X WangH L Zhang
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·C M Zmijewski
Sep 11, 2020·Expert Review of Gastroenterology & Hepatology·Manori Vijaya KumariNiranga Manjuri Devanarayana

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.