The association of aneuploidy and mild fetal pyelectasis in an unselected population: the results of a multicenter study

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
P M ChudleighS Campbell

Abstract

Mild pyelectasis is a common finding and there is some debate as to its association with aneuploidy. The results of a large, prospective, multicenter study of mild pyelectasis designed to determine the incidence and association with aneuploidy in an unselected population are reported. A large multicenter, prospective observational study of unselected fetuses with mild pyelectasis identified between 16 and 26 weeks' gestation in routine ultrasound departments. There were 737 fetuses with mild pyelectasis of which 12 had an abnormal karyotype. Pyelectasis was isolated in three fetuses with Down syndrome, but in one the mother was older (36 years). These data confirm the fact that the presence of mild fetal pyelectasis increases the risk for aneuploidy, in particular trisomy 21. However, other risk factors should be considered before embarking on fetal karyotyping, as for most pregnancies complicated by isolated mild pyelectasis, risks of aneuploidy will remain small.

References

Jan 1, 1992·Fetal Diagnosis and Therapy·K H NicolaidesC Gosden
Feb 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R GonenS Degani
Jun 1, 1996·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J G OuzounianB W Kovacs
Oct 1, 1996·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E WickstromE Pergament

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Citations

Apr 9, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·G Ahmad, P Green
Jan 19, 2016·Seminars in Perinatology·Rashmi Rao, Lawrence D Platt
Apr 20, 2010·Journal of Pediatric Urology·Hiep T NguyenJeffrey B Campbell
Oct 28, 2015·Journal of Perinatal Medicine·Alaa EbrashyMilan Stanojevic
Apr 4, 2006·Obstetrics and Gynecology·Eran BornsteinMichael Y Divon
Jan 9, 2007·Clinical Radiology·K A Duncan
Mar 26, 2005·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T E Cohen-OverbeekK P Wolffenbuttel
Dec 9, 2004·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·H A M Damen-EliasG H A Visser
Nov 25, 2003·Prenatal Diagnosis·Lyn S Chitty, Douglas G Altman
Mar 29, 2011·Prenatal Diagnosis·Jeanine F CarboneAnthony O Odibo
Jan 18, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Marino SignorelliUmberto A Bianchi
Apr 6, 2004·Obstetrics and Gynecology Clinics of North America·Meredith Rochon, Keith Eddleman
Aug 5, 2008·The Journal of Pediatrics·Vivian Yee-fong LeungConstantine Metreweli
Sep 10, 2005·American Journal of Obstetrics and Gynecology·Claudio Coco, Philippe Jeanty
Mar 3, 2007·American Journal of Primatology·Charleen M MooreNatalia E Schlabritz-Loutsevitch
Jul 26, 2005·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Joseph R WaxJacquelyn Blackstone
Apr 22, 2004·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Anthony O OdiboGeorge A Macones

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