The association of angina pectoris with heart disease mortality among men and women by diabetes status: the Rancho Bernardo Study.

Journal of Women's Health
Kimbach T CarpiucElizabeth Barrett-Connor

Abstract

To study the sex-specific association of angina pectoris with mortality in community-dwelling older adults with and without diabetes. Baseline prevalence of angina was evaluated in 822 men and 1184 postmenopausal women aged 50-89 years at the 1984-1987 Rancho Bernardo Study clinic visit, when an oral glucose tolerance test (OGTT) and the Rose angina questionnaire were administered. All-cause and coronary heart disease (CHD) mortality were assessed after an average follow-up period of 13.2 years. Sex-specific Cox proportional hazard models were used to examine the independent association of angina with mortality by glucose tolerance category. At baseline, average age was 71 years for both sexes; 61 men (7.4%) and 142 women (12.0%) had angina. Overall, 129 men (15.9%) and 130 women (11.0%) had type 2 diabetes; 228 men (27.7%) and 357 women (30.2%) had impaired glucose tolerance (IGT). During follow-up, 485 men (59%) and 557 women (47%) died, of whom 103 men (21.2%) and 104 women (18.7%) had fatal CHD. Women with diabetes and angina had a 3-4-fold greater risk of dying from CHD than women with diabetes but without angina, independent of covariates. Women with angina and IGT had twice the risk of CHD mortality compared with women w...Continue Reading

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Citations

Sep 3, 2002·Journal of the American College of Cardiology·Steven P Marso
Jun 18, 2014·Journal of Receptor and Signal Transduction Research·Armando Ruiz-HernándezSantiago Villafaña
Nov 30, 2019·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Njambi MathengeJulius M Gardin
Jan 1, 2018·Journal of Receptor and Signal Transduction Research·Armando Ruiz-HernándezSantiago Villafaña
Nov 23, 2011·Expert Review of Cardiovascular Therapy·Ki E Park, Carl J Pepine
Jun 25, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Melissa E ReicheltLea M D Delbridge

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