The association of anti-CCP antibodies with disease activity in rheumatoid arthritis.

Rheumatology International
Münevver SerdaroğluSibel Kul

Abstract

Antibodies to citrullinated proteins have been described in patients with rheumatoid arthritis (RA) and these appear to be the most specific markers of the disease. Our objective was to determine the frequency of antibodies to cyclic citrullinated peptides (CCPs) in patients with RA and the association of anti-CCP antibodies with disease activity, radiological erosions and HLA DR genotype. Forty patients with RA and 38 patients with fibromyalgia were included in this study. Serum samples were collected from both patient groups with RA and fibromyalgia. Anti-CCP was measured by the corresponding enzyme-linked immunosorbent assay. Additionally, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), disease activity score (DAS), visual analog scala (VAS), HLA genotype and radiographic information were determined in patients with RA. The rate of sensitivity and specificity of anti-CCP reactivity for the diagnosis RA were measured (sensitivity 50%, specificity 100%). There is no significant difference between anti-CCP (+) and anti-CCP (-) RA patients for DAS28, VAS, ESR, CRP, disease duration, HLA genotype, and radiological assessment of hand. However, there was a significant difference between anti-...Continue Reading

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Citations

May 16, 2009·Rheumatology International·Burcu ÖnderMüfit Akyüz
Dec 22, 2011·Rheumatology International·Kamal EsalatmaneshMohammadreza Nikbakht
Oct 2, 2013·Nuklearmedizin. Nuclear Medicine·I KarapolatK Kumanlioglu
Jul 15, 2009·Clinical Rheumatology·Licia Maria Henrique da MotaJozélio Freire de Carvalho
Jun 4, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maria InfantinoMaurizio Benucci
Jan 5, 2011·Autoimmunity Reviews·Rossana ScrivoGuido Valesini
Apr 14, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Bor-Show TzangTsai-Ching Hsu
Mar 6, 2012·Autoimmunity Reviews·Scott M Hayter, Matthew C Cook

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
ESR

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