The association of bone and osteoclasts with vascular calcification

Vascular Medicine
Kum Hyun HanW Charles O'Neill

Abstract

The presence of bone tissue in calcified arteries may provide insights into the pathophysiology and potential reversibility of calcification, but the prevalence, distribution, and determinants of bone and osteoclasts in calcified arteries are unknown. Specimens of 386 arteries from lower limb amputations in 108 patients were examined retrospectively. Calcification was present in 282 arteries from 89 patients, which was medial in 64%, intimal in 9%, and both in 27%. Bone was present in 6% of arteries, essentially all of which were heavily calcified. Multiple sampling revealed that the true prevalence of bone in heavily calcified arteries was 25%. Bone was more common in medial rather than intimal calcifications (10% vs 3%, p=0.03) but did not vary with artery location (above vs below the knee). Heavily calcified arteries with bone were more likely to come from patients who were older (p=0.04), had diabetes (p=0.06), or were receiving warfarin (p=0.06), but there was no association with gender or renal failure. Bone was almost always adjacent to calcifications, along the periphery, but never within. Staining for the bone-specific proteins osteocalcin and osterix was noted in 20% and 45% of heavily calcified arteries without visib...Continue Reading

References

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Citations

Jun 18, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Chin Yee Ho, Catherine M Shanahan
Mar 1, 2019·Cardiovascular Research·Megan NashMary M Kavurma
Apr 13, 2018·Scientific Reports·Carolin BauerZouhair Aherrahrou
Dec 14, 2019·Advances in Chronic Kidney Disease·Edward R SmithStephen G Holt
Jul 14, 2020·PloS One·Sabine R ZwakenbergUNKNOWN SMART Study Group
May 11, 2021·Frontiers in Cardiovascular Medicine·Wenhong JiangXiao Qin
Aug 5, 2021·Scandinavian Journal of Clinical and Laboratory Investigation·Birgitta JönelidAgneta Siegbahn
Nov 21, 2017·Kidney International·W Charles O'Neill

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Methods Mentioned

BETA
amputations
amputation

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