The association of calcium oxalate deposition in kidney allografts with graft and patient survival.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Ragnar PalssonSushrut S Waikar

Abstract

Whether calcium oxalate (CaOx) deposition in kidney allografts following transplantation (Tx) adversely affects patient outcomes is uncertain, as are its associated risk factors. We performed a retrospective cohort study of patients who had kidney allograft biopsies performed within 3 months of Tx at Brigham and Women's Hospital and examined the association of CaOx deposition with the composite outcome of death or graft failure within 5 years. Biopsies from 67 of 346 patients (19.4%) had CaOx deposition. In a multivariable logistic regression model, higher serum creatinine [odds ratio (OR) = 1.28 per mg/dL, 95% confidence interval (CI) 1.15-1.43], longer time on dialysis (OR = 1.11 per additional year, 95% CI 1.01-1.23) and diabetes (OR = 2.26, 95% CI 1.09-4.66) were found to be independently associated with CaOx deposition. CaOx deposition was strongly associated with delayed graft function (DGF; OR = 11.31, 95% CI 5.97-21.40), and with increased hazard of the composite outcome after adjusting for black recipient race, donor type, time on dialysis before Tx, diabetes and borderline or acute rejection (hazard ratio 1.90, 95% CI 1.13-3.20). CaOx deposition is common in allografts with poor function and portends worse outcomes up...Continue Reading

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Citations

Mar 5, 2019·JAMA Internal Medicine·Sushrut S WaikarUNKNOWN Chronic Renal Insufficiency Cohort study investigators
Jul 15, 2020·Journal of the American Society of Nephrology : JASN·Laura I NeumeierFelix Knauf
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Jan 9, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anja PfauFelix Knauf
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Jul 21, 2021·Journal of the American Society of Nephrology : JASN·Anja PfauFelix Knauf
Jan 6, 2022·Journal of Synchrotron Radiation·Emmanuel EstèveMatthieu Réfrégiers

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