The Association of Coagulation Factor V (Leiden) and Factor II (Prothrombin) Mutations With Stroke

Iranian Red Crescent Medical Journal
Maryam PirhoushiaranAriane Sadr Nabavi

Abstract

Epidemiological studies indicate that over the past forty years, the stroke incidence rates has increased. Factors V and II mutations are established genetic-variant risk factors for venous thrombosis; however, their contribution to stroke is a controversial issue. This study aimed to investigate the potential association of FV and FII mutations with stroke in an Iranian population. The study population consisted of 153 patients of different stroke subtypes (except cryptogenic strokes), admitted to Ghaem Hospital, Mashhad, Iran. The control group included 153 age- and sex-matched subjects without a history of cerebrovascular or neurologic diseases. Mutations of FV and FII were determined by using a TaqMan SNP Genotyping technique. The chi-square and Exact Fisher tests were used to analyze the baseline characteristics. Results were as follows: The calculated P-value for sex and diabetes mellitus were 0.907 and 1.000, respectively. The case and control groups were also matched in low density lipoprotein (P = 0.816), high density lipoprotein (P = 0.323), triglyceride (P = 0.846), and total cholesterol (P = 0.079). Analysis of the FV showed that none of the study subjects were AA homozygous for this mutation and only 6 heterozygous...Continue Reading

References

Jul 9, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·M MargaglioneG Di Minno
Aug 24, 1999·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·M GaustadnesJ Ingerslev
Sep 13, 2001·British Journal of Haematology·UNKNOWN Haemostasis and Thrombosis Task Force, British Committee for Standards in Haematology
Nov 8, 2001·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·S LopaciukH Jedrzejowska
Jan 10, 2002·Stroke; a Journal of Cerebral Circulation·Pasquale MadonnaGiovanni Di Minno
Jun 19, 2002·Blood·Klaus JuulBørge Grønne Nordestgaard
Jul 26, 2002·Clinical Neurology and Neurosurgery·E B Gómez GarciaD W J Dippel
Nov 20, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·R GrossmannS Schwender
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Aug 30, 2003·Stroke; a Journal of Cerebral Circulation·A SantamaríaJ Fontcuberta
Dec 20, 2003·Stroke; a Journal of Cerebral Circulation·Enrico FlossmannPeter M Rothwell
Apr 30, 2004·Thrombosis and Haemostasis·Justo AznarAmparo Estellés
Feb 5, 2005·Stroke; a Journal of Cerebral Circulation·Alessandro PezziniAlessandro Padovani
Mar 23, 2005·Archives of Disease in Childhood·S HaywoodV Ganesan
Jun 11, 2005·Journal of Thrombosis and Haemostasis : JTH·A J C SlooterA Algra
Sep 17, 2005·Stroke; a Journal of Cerebral Circulation·Danish SaleheenPhilippe Frossard
Dec 6, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S RubattuM Rasura
May 3, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Adriano de Paula SabinoAna Paula Fernandes
Feb 27, 2007·Stroke; a Journal of Cerebral Circulation·Josep RedónUNKNOWN Investigators of the PREV-ICTUS study
Aug 19, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·Thomas A Burke, Ramani N Venketasubramanian
Mar 4, 2011·BMC Medical Genetics·Sunaina YadavPankaj Sharma

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Citations

Aug 23, 2019·Current Drug Targets·Reza Jafarzadeh-EsfehaniAriane Sadr Nabavi

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Methods Mentioned

BETA
genotyping

Software Mentioned

Ghaem Hospital information system ( HIS )
SPSS

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