PMID: 9642639Jun 27, 1998Paper

The association of congenital hypothyroidism and congenital gastrointestinal anomalies in Down's syndrome infants

Journal of Pediatric Endocrinology & Metabolism : JPEM
S JaruratanasirikulC Patanapisarnsak

Abstract

To study the prevalence of congenital hypothyroidism in infants with Down's syndrome and to verify whether there is an association with other congenital defects. This is a prospective study of 112 Down patients, less than 1 year of age, who attended Songklanagarind Hospital from January 1991 to December 1996. Free T4 and TSH determinations were performed in all Down infants. Information on karyotype, sex, maternal age and other congenital anomalies was collected. Congenital hypothyroidism was detected in 17 patients (15.2%); 3 overt congenital hypothyroidism; 6 persistent compensated hypothyroidism; and 8 transient compensated hypothyroidism. Nine of the 20 patients (45%) with congenital gastrointestinal anomalies had congenital hypothyroidism, while 8 out of 92 patients (8.7%) without congenital gastrointestinal anomalies had congenital hypothyroidism. The odds ratio was 8.59 (95% confidence interval 2.4-31.6; p = 0.0001). Congenital hypothyroidism has a relatively high prevalence rate in Down infants and tends to occur in Down patients with gastrointestinal anomalies.

References

Dec 27, 1975·Lancet·R H DavisH G Hill
Sep 1, 1978·Clinical Genetics·Z SareV C Kelley
Nov 1, 1979·The Journal of Pediatrics·J L BallardM Driver
Jan 1, 1991·Research in Developmental Disabilities·S M PueschelJ C Pezzullo
Dec 1, 1985·Archives of Disease in Childhood·M M LoudonE M Duke
Nov 1, 1972·The Journal of Pediatrics·A H KleinF M Kenny
Oct 1, 1971·Archives of Disease in Childhood·S Raiti, G H Newns
Apr 1, 1984·The Journal of Pediatrics·P FortR David
May 1, 1993·Developmental Medicine and Child Neurology·M Selikowitz
Sep 1, 1965·The Journal of Pediatrics·K M SAXENA, C V PRYLES

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Citations

Dec 18, 2007·Annals of Human Genetics·M-M Garcia-BarcelóP K Tam
Jun 20, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·I B PurdyU P Devaskar
Mar 6, 2017·Hormone Research in Pædiatrics·Melinda J PierceJoseph D Pinter
Feb 14, 2018·BMJ Case Reports·Maria Chiara De NardoDeena Patel
Jul 21, 2007·Annals of Human Genetics·Maria-Mercè Garcia-BarcelóPaul Kwong-hang Tam
Jul 13, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Valeria CalcaterraDaniela Larizza
Sep 1, 2015·Expert Review of Endocrinology & Metabolism·Lorenzo IughettiBarbara Predieri
Jan 20, 2017·World Journal of Pediatrics : WJP·Somchit JaruratanasirikulPongsak Tantichantakarun

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