The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysis

International Journal of Cancer. Journal International Du Cancer
Xiang-Lin TanJenny Chang-Claude

Abstract

Cyclin D1 (CCND1) and E-cadherin (CDH1) have been shown to be important genes of the beta-catenin/LEF pathway that is involved in colorectal carcinogenesis. However, epidemiological studies on relationship between genetic variants of these two genes and colorectal cancer (CRC) have shown inconsistent results. In a population-based case-control study (498 cases and 600 controls), we assessed the association of CCND1 G870A and CDH1 C-160A polymorphisms with CRC risk. Multivariable logistic regression analysis was used to estimate the association between genotypes, environmental exposures and CRC risk, adjusting for potential confounders. Compared to common homozygotes, the OR for heterozygous and homozygote variant genotype was 1.08 (95% CI, 0.80-1.46) in CCND1 and 0.97 (95% CI, 0.75-1.25) in CDH1. Neither tumor stage nor location showed an association with genetic susceptibility. However, a significant interaction between hormone replacement therapy (HRT) and CCND1 genotypes in CRC risk was found among postmenopausal women (p(interaction) = 0.02). The risk reduction associated with HRT was substantial (OR, 0.09; 95% CI, 0.02-0.35) in women who were GG homozygous. A meta-analyses including 11 published studies on CCND1 G870A in a...Continue Reading

References

Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Mar 31, 1999·Trends in Biochemical Sciences·G Christofori, H Semb
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·M ShtutmanA Ben-Ze'ev
May 21, 1999·The American Journal of Medicine·F GrodsteinM J Stampfer
Aug 30, 2000·International Journal of Cancer. Journal International Du Cancer·J A McKayH L McLeod
Dec 5, 2000·Frontiers in Bioscience : a Journal and Virtual Library·B T ZafonteR G Pestell
Jul 19, 2001·Journal of the National Cancer Institute·S KongM L Frazier
Sep 29, 2001·Journal of Clinical Epidemiology·J A Sterne, M Egger
Feb 14, 2002·Experimental Cell Research·Irene H L HamelersPaul H Steenbergh
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Haixin LeiIgor Vorechovský
Mar 23, 2002·Climacteric : the Journal of the International Menopause Society·E C DudleyL Dennerstein
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Bas A J VerhageJack A Schalken
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Paul D P PharoahDavid Huntsman
Dec 6, 2003·JAMA : the Journal of the American Medical Association·Loïc Le MarchandLynne R Wilkens
Feb 13, 2004·International Journal of Cancer. Journal International Du Cancer·Björn-Anders JonssonHenrik Grönberg
Nov 17, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Robin L KilkerMaricarmen D Planas-Silva
Mar 3, 2005·Japanese Journal of Clinical Oncology·Toshiyuki KamotoOsamu Ogawa
Apr 6, 2005·Evolution; International Journal of Organic Evolution·Michael S Rosenberg
May 3, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yi HongPeh Yean Cheah
Nov 1, 2005·Cell Cycle·Serge Y FuchsToshinari Minamoto
Dec 6, 2005·Journal of Cancer Research and Clinical Oncology·Jing JiangShinkan Tokudome
Dec 24, 2005·The Prostate·Carolina BonillaRick A Kittles
Jan 26, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Carmen LillaJenny Chang-Claude
Feb 24, 2006·British Journal of Cancer·E S SchernhammerC S Fuchs
Mar 23, 2006·Diseases of the Colon and Rectum·Wen-Shih HuangLing-Ling Hsieh
Jul 4, 2006·The Journal of Urology·Deepa PookotRajvir Dahiya
Aug 29, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lambertus A KiemeneyGerald W Verhaegh

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Citations

May 29, 2008·JAMA : the Journal of the American Medical Association·Linda M DongUlrike Peters
May 6, 2011·International Journal of Colorectal Disease·Lou-Qian ZhangJian-Nong Zhou
Oct 15, 2011·International Journal of Colorectal Disease·Yadong WangXiangqun Xia
Sep 27, 2008·Breast Cancer Research and Treatment·Cheng LuHongbing Shen
Sep 29, 2012·Journal of the National Cancer Institute·Evropi TheodoratouJulian Little
Aug 9, 2011·BMC Cancer·Anna AbulíUNKNOWN Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
May 19, 2010·Biomarkers in Medicine·Hirendra Nath Banerjee, Mukesh Verma
Apr 18, 2009·Journal of Gastrointestinal Cancer·Nora Manoukian ForonesIsmael Dale Cotrim Guerreiro da Silva
Sep 9, 2008·Critical Reviews in Oncology/hematology·Peh Yean Cheah
Jul 2, 2009·International Journal of Cancer. Journal International Du Cancer·Alan M PittmanRichard S Houlston
Oct 16, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Abitha MuraliS Kannan
Mar 27, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chung-Yu HuangDa-Tian Bau
Nov 26, 2010·Journal of Human Genetics·Carolina BonillaWalter F Bodmer
May 30, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Qi-Wen DengShu-Kui Wang
Jun 11, 2016·Molecular and Clinical Oncology·Xiao-Ming XuMing Shen
Jan 29, 2013·Molecular Medicine Reports·Aga Syed SameerMushtaq A Siddiqi

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