The association of diabetes mellitus and insulin treatment with expression of insulin-related proteins in breast tumors

BMC Cancer
Heleen K BronsveldMarjanka K Schmidt

Abstract

The insulin receptor (INSR) and the insulin growth factor 1 receptor (IGF1R) play important roles in the etiology of both diabetes mellitus and breast cancer. We aimed to evaluate the expression of hormone and insulin-related proteins within or related to the PI3K and MAPK pathway in breast tumors of women with or without diabetes mellitus, treated with or without insulin (analogues). Immunohistochemistry was performed on tumor tissue of 312 women with invasive breast cancer, with or without pre-existing diabetes mellitus, diagnosed in 2000-2010, who were randomly selected from a Danish breast cancer cohort. Women with diabetes were 2:1 frequency matched by year of birth and age at breast cancer diagnosis to those without diabetes. Tumor Microarrays were successfully stained for p-ER, EGFR, p-ERK1/2, p-mTOR, and IGF1R, and scored by a breast pathologist. Associations of expression of these proteins with diabetes, insulin treatment (human insulin and insulin analogues) and other diabetes medication were evaluated by multivariable logistic regression adjusting for menopause and BMI; effect modification by menopausal status, BMI, and ER status was assessed using interactions terms. We found no significant differences in expression...Continue Reading

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Citations

Aug 7, 2019·Analytical and Bioanalytical Chemistry·Giselda BezerraJosé Lima-Filho
Jul 4, 2020·Signal Transduction and Targeted Therapy·Zhe ZhangCanhua Huang
Mar 24, 2021·Molecular and Cellular Endocrinology·Flávia Sardela de MirandaNaima Moustaid-Moussa

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Software Mentioned

SAS Enterprise guide
R studio
Multivariate Imputations by Chained Equations ( MICE )

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