The Association of Dietary Polyphenol Intake with the Risk of Type 2 Diabetes: Tehran Lipid and Glucose Study

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
Zohreh EsfandiarFereidoun Azizi

Abstract

The current study aimed to investigate the relationship between daily consumption of total polyphenol and its subclasses and the incidence of diabetes. Eligible adults (n=6,547) were chosen from among participants of the Tehran Lipid and Glucose Study (TLGS) with an average follow-up of 3.0±1.6 years. Dietary intakes were evaluated using a valid and reliable semi-quantitative food frequency questionnaire. Biochemical variables and anthropometrics were evaluated at baseline and follow-up examinations. Multivariate Cox proportional hazard regression models were used to estimate the development of type 2 diabetes mellitus (T2DM) in relation to total intake of polyphenol and its subclasses (flavonoids, phenolic acids, stilbenes, and lignans). This study was conducted on 2,882 men and 3,665 women, aged 41.3±14.6 and 39.0±13.4 years, respectively. The number of participants with the new-onset T2DM was 253. Mean intake of total polyphenol was 346±245 mg/1000 kcal. Risk of type 2 diabetes decreased from quartiles 1 to 4 for total polyphenols (HR: 1.00, 0.37, 0.61, 0.50, Ptrend<0.01), phenolic acids (HR: 1.00, 0.57, 0.49, 0.45, Ptrend<0.01), and lignans (HR: 1.00, 0.67, 0.61, 0.60, Ptrend<0.01), whereas non-significant results were foun...Continue Reading

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