PMID: 9160381Apr 1, 1997Paper

The association of early-onset fetal growth restriction, elevated maternal serum alpha-fetoprotein, and the development of severe pre-eclampsia

Prenatal Diagnosis
T D Shipp, L Wilkins-Haug

Abstract

From Antenatal Diagnostic Center referrals over 22 months, consultations for early-onset fetal growth restriction versus skeletal dysplasia were retrospectively identified. Those with elevated maternal serum alpha-fetoprotein (MSAFP) levels are the focus of this report. All had an early ultrasound confirming menstrual dates and subsequent sonography at < 28 weeks with at least two fetal biometric measures delayed by > or = 2 standard deviations from mean values. Of the five patients identified, the mean gestational age at the time of diagnosis of fetal growth restriction was 23.3 +/- 2.9 weeks. All had normal karyotypes and normal amniotic fluid AFP. None of the patients had evidence of hypertension or pre-eclampsia at diagnosis of fetal growth restriction. All five gravidas subsequently developed severe pre-eclampsia from 5.5 to 12.5 weeks after documentation of fetal growth delay. Three developed HELLP syndrome. Pregnancies were continued a mean duration of 10-2 weeks, with all five delivering at preterm gestations (mean = 33.5 +/- 1.7 weeks) for maternal indications of severe pre-eclampsia. Unexplained early-onset fetal growth restriction in conjunction with unexplained elevations of MSAFP together consistently heralded the ...Continue Reading

References

Aug 6, 1977·Lancet·N WaldA C Turnbull
Nov 1, 1990·Obstetrical & Gynecological Survey·V L KatzR C Cefalo
May 1, 1988·American Journal of Obstetrics and Gynecology·C M SalafiaM J Mahoney
Apr 1, 1985·British Journal of Obstetrics and Gynaecology·B N WaltersM De Swiet
Mar 1, 1987·Journal of Clinical Ultrasound : JCU·E MerzS Pehl
Oct 29, 1983·British Medical Journal·B N WaltersM de Swiet
Nov 1, 1980·American Journal of Obstetrics and Gynecology·R K Tamura, R E Sabbagha
Oct 1, 1994·American Journal of Obstetrics and Gynecology·W F BrazerolA E Donnenfeld

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Citations

Feb 13, 2010·The Journal of Obstetrics and Gynaecology Research·Minoru MitaniHiroaki Ohta
Mar 30, 2000·American Journal of Obstetrics and Gynecology·D M StamilioG A Macones
Dec 12, 2003·Obstetrical & Gynecological Survey·Gerald J Mizejewski
Feb 27, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Simi GuptaNathan S Fox

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