The Association of Endothelin-1 with Markers of Arterial Stiffness in Black South African Women: The SABPA Study

Journal of Amino Acids
Christine Susara du PlooyRuan Kruger

Abstract

Background. Limited data exist regarding endothelin-1 (ET-1), a vasoactive contributor in vascular tone, in a population subjected to early vascular deterioration. We compared ET-1 levels and explored its association with markers of arterial stiffness in black and white South Africans. Methodology. This cross-sectional substudy included 195 black (men: n = 99; women: n = 95) and 197 white (men: n = 99; women: n = 98) South Africans. Serum ET-1 levels were measured as well as markers of arterial stiffness (blood pressure, pulse wave velocity, and arterial compliance). ET-1 levels were higher in black men and white women compared to their counterparts after adjusting for C-reactive protein. In both single and partial (adjusting for body mass index and gamma glutamyl transferase) regression analyses ET-1 correlated with age, interleukin-6, high density lipoprotein cholesterol, systolic blood pressure, pulse pressure, and pulse wave velocity in black women. In multivariate regression analyses the independent association of ET-1 with systolic blood pressure (Adj. R (2) = 0.13; β = 0.28, p < 0.01) and pulse pressure (Adj. R (2) = 0.11; β = 0.27, p < 0.01) was confirmed in black women only. ET-1 additionally associated with interleuki...Continue Reading

References

Aug 1, 1994·Journal of the American College of Cardiology·D S CelermajerJ E Deanfield
May 1, 1993·Journal of Applied Physiology·K H WesselingJ J Schreuder
Oct 1, 1995·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·S Komatsumoto, M Nara
Apr 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W F Keane, G Eknoyan
Mar 6, 2002·Circulation·Peter LibbyAttilio Maseri
Mar 13, 2002·Circulation·Johann W AuerBernd Eber
Jun 12, 2002·Circulation·Scott M Grundy
Sep 25, 2002·Psychosomatic Medicine·Frank A TreiberDavid M Pollock
Jul 2, 2003·Diabetes Care·James D CameronChakravarthi Rajkumar
Dec 10, 2003·Journal of the American College of Cardiology·Carmel M McEnieryIan B Wilkinson
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Susan J ZiemanDavid A Kass
Feb 25, 2006·The Canadian Journal of Cardiology·Todd J Anderson
Sep 28, 2006·Annual Review of Pharmacology and Toxicology·Markus P SchneiderDavid M Pollock
Jul 10, 2007·Cardiovascular Research·Felix Böhm, John Pernow
Feb 28, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Sarah Connor GorberMark Tremblay
May 26, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Anthony J DonatoDouglas R Seals
Nov 10, 2009·Behavior Research Methods·Franz FaulAlbert-Georg Lang
Jan 21, 2011·Physiological Reviews·Donald E KohanDavid M Pollock
Feb 5, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Adviye Ergul
Oct 1, 2011·Clinical and Experimental Hypertension : CHE·Aletta E SchutteManja Reimann
Oct 27, 2014·International Journal of Epidemiology·Leoné MalanNicolaas T Malan

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Citations

Sep 30, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Christine Susara du PlooyRuan Kruger
Sep 20, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R Matthew BrothersPaul J Fadel

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BETA
enzyme linked immunosorbent assay
ELISA

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Beatscope
Graphpad
SPSS Statistics
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