PMID: 8943105Nov 1, 1996Paper

The association of gut-associated lymphoid tissue and bacterial translocation in the newborn rabbit

Journal of Pediatric Surgery
M UraoA G Coran

Abstract

The authors have previously demonstrated spontaneous bacterial translocation (BT) in newborn rabbits and its resolution with aging. It is hypothesized that this spontaneous BT was associated with an immature gut-associated lymphoid tissue (GALT). The aim of the present study was to characterize the cellular populations of the GALT in rabbits at various ages and to correlate this with the frequency of BT. Small bowel (SB) sections and mesenteric lymph nodes (MLN) were harvested and cultured (aerobically) from New Zealand White rabbits at 0, 6, 14, 28, and more than 90 days of age for determination of bacterial colonization (BC) and BT. Portions of ileum (n = 6 for each age) were simultaneously harvested for immunoperoxidase staining. Total T cells (CDS+), expressed as the number of positive cells/1000 nuclei and activated T cells (CD25+), expressed as the number of positive cells/1000 nuclei and as the ratio of CD25+/CD5+ cells, were analyzed for each tissue. Positive cells were counted in 30 villi by light microscopy. The incidence of BT rose as BC increased in the small bowel and peaked at 6 days of age; BT then decreased with age. CD5+ cells in the small bowel villi at 0 days of age were few (2.5 positive cells/1000 nuclei) a...Continue Reading

References

Oct 1, 1978·The American Journal of Clinical Nutrition·W E MooreL V Holdeman
Nov 1, 1978·The Journal of Experimental Medicine·A J Husband, J L Gowans
Jan 1, 1992·The Journal of Surgical Research·J A AlverdyD A Burke
Aug 1, 1986·Archives of Disease in Childhood·W F Knox
Mar 1, 1985·The Journal of Pediatrics·P E HymanI L Taylor
Jan 1, 1968·International Archives of Allergy and Applied Immunology·P A CrabbéJ F Heremans
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Nov 1, 1980·The American Journal of Clinical Nutrition·R D Berg
Jan 1, 1994·Acta Paediatrica. Supplement·A M Kosloske
Jan 1, 1994·Acta Paediatrica. Supplement·E A Deitch

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Citations

Apr 17, 2003·The Journal of Surgical Research·Hua YangDaniel H Teitelbaum
May 11, 2010·Nutrition Research Reviews·Isabelle Le Huërou-LuronGaëlle Boudry
Oct 19, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Xiaoyi SunDaniel H Teitelbaum
Dec 1, 2001·Pediatric Research·G SteinwenderH H Wenzl
Sep 22, 2010·Pediatric Research·Gaëlle BoudryIsabelle LE Huërou-Luron
Apr 29, 2011·PloS One·Salvatore PapasergiShaynoor Dramsi
Mar 24, 2009·Journal of Pediatric Surgery·Cristiano BonetiSamuel D Smith
Feb 1, 2005·Annals of the New York Academy of Sciences·Jan-Olaf Gebbers, Jean-Albert Laissue
Mar 3, 1999·Journal of Pediatric Surgery·M UraoT Miyano
Sep 11, 2004·International Journal of Food Microbiology·Cheng-Chih TsaiHau-Yang Tsen
Oct 6, 1998·The Journal of Surgical Research·I Kiristioglu, D H Teitelbaum
Feb 3, 2015·Journal of Pediatric Gastroenterology and Nutrition·Claire Joly CondetteHafida Khorsi-Cauet
Oct 23, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·L EddeM P Sherman
Aug 1, 1997·Journal of the Royal Society of Medicine·A Bianchi
Nov 10, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xiaoyi SunDaniel H Teitelbaum

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