The association of Helicobacter pylori infection with serum lipid profiles: An evaluation based on a combination of meta-analysis and a propensity score-based observational approach

PloS One
Takeshi ShimamotoKazuhiko Koike

Abstract

Several previous studies have suggested that Helicobacter pylori (H. pylori) infection affects the serum lipid profile. However, it remains controversial and the mechanism has not been elucidated. The purpose of this study is to use an epidemiological perspective to evaluate the association between H. pylori infection and the serum lipid profile. Multivariate analysis was performed using the data of serum lipid profile, infection status of H. pylori, fitness/lifestyle habits, and various subjects' characteristics which were derived from the 15,679 generally healthy individuals in Japan. The average treatment effects (ATEs) of H. pylori infection on the serum lipid profile were estimated using augmented inverse probability weighting (AIPW). A meta-analysis was also performed using the 27 studies worldwide in which the status of H. pylori infection and at least one serum examination value (high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), or triglyceride (TG)) were described. The ATEs determined with AIPW showed that H. pylori infection has significant positive effects on LDL-C and TC (ATE (95% confidence interval [95%CI]) = 3.4 (2.36-4.49) and 1.7 (0.58-2.88), resp...Continue Reading

References

Oct 17, 1991·The New England Journal of Medicine·J ParsonnetR K Sibley
Oct 17, 1991·The New England Journal of Medicine·A NomuraM J Blaser
Nov 13, 1969·The New England Journal of Medicine·J I GallinW M O'Leary
Feb 27, 2001·Statistics in Medicine·P MacaskillL Irwig
Aug 21, 2001·Gut·T AzumaT Kato
Oct 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Hiroyuki OsawaKentaro Sugano
Nov 24, 2004·The American Journal of Gastroenterology·Atsushi TatsuguchiChoitsu Sakamoto
Sep 6, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuaki SaijoReiko Kishi
Jan 11, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M D KlokM L Drent
Mar 27, 2007·Best Practice & Research. Clinical Gastroenterology·Francesco Franceschi, Antonio Gasbarrini
Apr 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Jatin RoperMartin J Blaser
Jul 9, 2010·Journal of Atherosclerosis and Thrombosis·Hiroki SatohHiroyuki Tsutsui
Jun 19, 2013·Nature Reviews. Rheumatology·Jamie RobertsonNaveed Sattar
Aug 18, 2016·Helicobacter·Elisabetta Goni, Francesco Franceschi
Sep 12, 2017·Helicobacter·Jean-Dominique de KorwinAntonio Gasbarrini
Jul 6, 2018·Journal of Lipids·Mohamadreza HaeriJamshid Vafaeimanesh

❮ Previous
Next ❯

Citations

Mar 7, 2021·Journal of Clinical Medicine·Jun WatanabeKazuhiko Kotani
Jul 6, 2021·Frontiers in Endocrinology·Gracia M Martin-NuñezFrancisco J Tinahones

❮ Previous
Next ❯

Software Mentioned

R
RoBANS
Risk of Bias Assessment Tool for Nonrandomized Studies ( RoBANS )

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.