PMID: 8959900Jul 1, 1996Paper

The association of hepatitis C viral infection with porphyria cutanea tarda in the Lothian region of Scotland

Clinical and Experimental Dermatology
I HussainP C Hayes

Abstract

Porphyria cutanea tarda (PCT) is believed to be associated with reduced hepatic uroporphyrinogen decarboxylase activity and risk factors such as alcohol abuse and medication with oral contraceptives and certain other drugs. Recently it has been suggested that hepatitis C virus (HCV) infection may also be associated with PCT. We have therefore reviewed the prevalence of HCV infection in a series of patients with PCT in the Lothian region of Scotland. We identified 12 patients with PCT, all of whom had abnormal liver function tests. Liver histology revealed chronic active hepatitis in six patients, micronodular cirrhosis in four patients, hepatocellular carcinoma in one patient and normal findings in one HIV positive patient. Out of 12 patients tested, 11 were positive for anti-HCV antibodies by second generation enzyme linked immunosorbent assay (ELISA 2), and by recombinant immunoblot assay (RIBA 2); positive serology was confirmed by polymerase chain reaction (PCR). In a second group of 14 patients with chronic HCV infection matched for age and sex with the PCT patients, all had normal urinary uroporphyrin excretion. We have thus confirmed in Scotland early reports from Spain and Italy that PCT is strongly associated with HCV ...Continue Reading

References

Oct 31, 1978·Human Genetics·H de VerneuilY Nordmann
Dec 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S FargionG Fiorelli
Feb 1, 1989·The Journal of General Virology·M S CollettM C Horzinek
Jun 1, 1989·British Journal of Urology·I H Coulson, K Misch
Jul 1, 1988·Annals of Clinical Biochemistry·A C Deacon
Jul 1, 1970·Acta Medica Scandinavica·O LundvallP Lundin
Feb 1, 1983·Liver·J H Lefkowitch, M E Grossman
Apr 1, 1982·The New England Journal of Medicine·B F FelsherA T Nunn
Apr 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M DeCastroR Moreno-Otero
Jun 12, 1993·Lancet·A MurphyG M Murphy
Dec 1, 1994·Journal of the American Academy of Dermatology·G KoesterC Bigler

❮ Previous
Next ❯

Citations

Sep 16, 2003·Journal of Hepatology·Javier P GisbertRicardo Moreno-Otero
Aug 24, 1999·Journal of Hepatology·A L Zignego, C Bréchot
Apr 29, 1998·Clinics in Dermatology·F De Matteis
Oct 12, 2000·European Journal of Internal Medicine·Y NagaoT Ueno
Oct 27, 2001·Clinical and Experimental Immunology·Y MaS Fargion
Jun 1, 1997·Photodermatology, Photoimmunology & Photomedicine·H W Lim
Mar 20, 2004·Lancet·R S Dawe
Apr 7, 2010·The American Journal of Medicine·Adetunji A Adejumo, Sharon B Mannheimer
Jul 16, 2008·Clinics in Liver Disease·Anna Linda Zignego, Antonio Craxì
Apr 19, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·F Ryan CaballesHerbert L Bonkovsky
Aug 22, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David R BerkAijaz Ahmed
Aug 4, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A L ZignegoUNKNOWN Italian Association of the Study of Liver Commission on Extrahepatic Manifestations of HCV infection
May 4, 2001·Journal of Autoimmunity·P Obermayer-Straub, M P Manns
Mar 27, 2015·Current Infectious Disease Reports·Ahmed Akhter, Adnan Said
Jul 20, 1999·Journal of the American Academy of Dermatology·T Y ChuangC Lewis
Dec 10, 2020·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Afif YaccobSharmila Fagoonee
Dec 8, 1998·Journal of the American Academy of Dermatology·H W LimS Zolla-Pazner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

Photodermatology, Photoimmunology & Photomedicine
F M O'ReillyG M Murphy
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
S FargionG Fiorelli
© 2021 Meta ULC. All rights reserved