The association of HLA B*15:02 allele and Stevens-Johnson syndrome/toxic epidermal necrolysis induced by aromatic anticonvulsant drugs in a South Indian population

International Journal of Dermatology
Keerankulangara Devi

Abstract

The presence of HLA-B*15:02 allele is considered a risk factor for development of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in patients taking aromatic anticonvulsant drugs like carbamazepine and phenytoin. The genetic association is ethnicity specific. Testing for HLA-B*15:02 allele is suggested as a prerequisite before starting carbamazepine in certain ethnic groups. There are only a few/no studies from south India on HLA association of SJS/TEN. To identify any association between HLA-B*15:02 allele and SJS/TEN induced by carbamazepine/phenytoin among native population. METHODS (INCLUDING SETTINGS, DESIGN, AND STATISTICAL ANALYSIS USED): A case-control study done in a tertiary care center at Kottayam in Kerala state of south India. Cases were 12 native patients who developed SJS/TEN owing to aromatic anticonvulsant drugs (phenytoin - 8; carbamazepine - 4), and controls were 11 persons tolerant to these drugs from unrelated families of the same ethnic group. HLA-B typing was done by PCR SSP method. There was only one HLA-B*15:02 carrier among cases and controls. He/she had SJS/TEN induced by carbamazepine. Association of HLA-B*15:02 with phenytoin-induced SJS/TEN is rare in the population studied. The one l...Continue Reading

References

Apr 2, 2004·Nature·Wen-Hung ChungYuan-Tsong Chen
Jan 18, 2006·The Pharmacogenomics Journal·C LonjouUNKNOWN RegiSCAR Group
Mar 16, 2006·Pharmacogenetics and Genomics·Shuen-Iu HungYuan-Tsong Chen
Nov 17, 2009·Indian Journal of Dermatology, Venereology and Leprology·Timir Y MehtaRamesh K Goyal
Sep 16, 2011·Epilepsy Research·Sae-Hoon KimUNKNOWN Adverse Drug Reaction Research Group in Korea
May 6, 2015·Asia Pacific Allergy·Dinh Van NguyenSheryl van Nunen

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Citations

Jun 20, 2018·The Korean Journal of Internal Medicine·Jae-Woo JungHye-Ryun Kang
Jan 4, 2020·Allergy·Abderrahim OussalahUNKNOWN Task Force “Genetic predictors of drug hypersensitivity” of the European Network on Drug Allergy (ENDA), European Academy of

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