The association of HLA with young-onset keratoconus in Japan

American Journal of Ophthalmology
Wakako AdachiShigeru Kinoshita

Abstract

To report the association of HLA antigens with keratoconus in Japanese patients. Observational consecutive case series. In 90 consecutive Japanese keratoconus patients, HLA class I (HLA-A, -B, -C) and class II (HLA-DR, -DQ) were analyzed. Compared with control frequencies, based on mean gene frequencies for the Japanese population, higher frequencies of HLA-A26, B40, and DR9 antigens were found in patients whose conditions were diagnosed before 20 years of age (chi(2) = 6.45, P =.01; chi(2) = 6.78, P =.01; chi(2) =3.99, P =.05, respectively), but were not found in patients whose conditions were diagnosed later in life. Men were significantly younger at diagnosis than were women. No obvious relation was found between HLA antigens and other clinical data. HLA-A26, B40, and DR9, which were found relatively frequently in the ancient Japanese population, seem to be associated with keratoconus in younger individuals.

References

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Citations

Dec 20, 2005·The British Journal of Ophthalmology·S A Al-SwailemA A Al-Torbak
Oct 9, 2009·Optometry : Journal of the American Optometric Association·Heidi WagnerKarla Zadnik
Aug 4, 2015·The Ocular Surface·Robert P L WisseAllegonda Van der Lelij
Oct 22, 2013·Seminars in Ophthalmology·Han-Ying Peggy Chang, James Chodosh
Nov 24, 2005·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·M Cristina Kenney, Donald J Brown
Aug 6, 2009·Cornea·Nitin UdarM Cristina Kenney
Feb 9, 2012·Cornea·Yee Onn KokSeng Chee Loon
Mar 13, 2012·Cornea·Joel Sugar, Marian S Macsai
Aug 31, 2017·International Ophthalmology·Sabrina Mukhtar, Balamurali K Ambati
Aug 3, 2020·Cornea·Luca BuzzonettiPaola Valente

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