The Association of IL-1 Alpha Level and TNF Alpha Expressions on Bone Destruction in Chronic Suppurative Otitis Media and Cholesteatoma.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
ArtonoM Reza Mahardhika

Abstract

 Bone destruction in patients with chronic suppurative otitis media (CSOM) and cholesteatoma is considered to be quite high. Bone destruction is caused by various inflammatory cytokines and osteoclasts including IL-1α and TNF-α. The imbalance between the resorption process by osteoclasts and the process of bone formation is also a causative factor for bone destruction. On top of that, the large number of patients is not supported by an equal amount of medical facilities and personnel to conduct operative procedures. To analyze the associated of IL-1α level and TNF-α expression on the severity of bone destruction in CSOM and cholesteatoma patients. The total number of the subjects was 46 patients which group I (TNF-α) consisted of 26 individuals and group II (IL-1α) contained 26 individuals as well. The analysis was conducted in 2 different places (Solo, Indonesia and Surabaya, Indonesia). IL-1α expression was assessed by using ELISA kit at the absorbance rate of 450 nm whereas the rabbit anti-TNF-α polyclonal antibody was applied to examine TNF-α. The assessment of bone destruction was carried out during the operative procedure in Dr. Soetomo General Hospital Surabaya, Indonesia. Group I assessment resulted in severe bone destr...Continue Reading

References

May 22, 2002·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Jae Y Jung, Richard A Chole
Jul 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jung Ha KimNacksung Kim
Dec 18, 2009·American Journal of Otolaryngology·Jerzy KuczkowskiEwa Iżycka-Świeszewska
Jan 5, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Anna Moltó, Alejandro Olivé
Aug 4, 2010·International Immunology·Young-Mi LeeYoichiro Iwakura
Feb 12, 2011·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Jerzy KuczkowskiTadeusz Pawełczyk
Aug 2, 2012·Nature Reviews. Drug Discovery·Charles A DinarelloJos W M van der Meer
Feb 1, 2010·Therapeutic Advances in Musculoskeletal Disease·Laura C CoatesPaul Emery
May 17, 2014·The Pediatric Infectious Disease Journal·Ratna AnggraeniEric A F Simões
Dec 17, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Shumin XieWei Liu

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Citations

May 3, 2021·International Journal of Pediatric Otorhinolaryngology·Tankut UzunErdost Yıldız
Jun 2, 2021·International Journal of Surgery Case Reports·Sally MahdianiRiri Handayani
Jul 1, 2021·Annals of Medicine and Surgery·Sally MahdianiDenis Anugrah
Jul 8, 2021·Laryngo- rhino- otologie·Anke LeichtleKarl-Ludwig Bruchhage
Sep 21, 2021·Experimental and Therapeutic Medicine·Roxana SerbanBogdan Mihail Cobzeanu

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