Abstract
The proinflammatory cytokine interleukin (IL)-1 family has a central role in mediating inflammation and joint destruction in Graves' disease (GD). A number of studies, investigating rs1800587 (IL-1alpha, T-889 C) and rs16944 (IL-1beta, A-511 G) polymorphisms to test their possible association with GD and Graves' ophthalmopathy (GO), had inconsistent results. Our study aims to further evaluate the possible association of these two polymorphisms with GD and GO within the Han Chinese population using a case-control association study as well as a meta-analysis covering three previous studies from Taiwan, Iran, and Poland. Based on 760 Chinese GD patients, including 190 of GO cases among them, and 735 healthy control subjects, our data showed that the genotype or allele distributions of rs1800587 and rs16944 polymorphisms were significantly associated with GD (p = 0.003-0.049) and more so with GO (p = 0.001-0.021). The meta-analysis showed the risk-increasing effects for the TC and TT genotypes of rs1800587 in GD (odds ratio [OR] = 2.07, p = 0.03) and GO (OR = 3.22, p = 0.04), and a protective effect for the AA genotype of rs16944 in GD (OR = 0.70, p = 0.002) and GO (OR = 0.65, p = 0.02). The results confirmed that the rs1800587 (IL...Continue Reading
References
Jan 1, 1977·The Journal of Clinical Endocrinology and Metabolism·S C Werner
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
May 12, 2000·Critical Care Medicine·A OberholzerL L Moldawer
May 29, 2000·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·A K RasmussenU Feldt-Rasmussen
Jun 8, 2000·The Journal of Clinical Endocrinology and Metabolism·P J HuntK I Welsh
Jun 22, 2000·Genomics·S J BusfieldY Pan
Nov 9, 2000·The New England Journal of Medicine·A P Weetman
Feb 21, 2003·Thyroid : Official Journal of the American Thyroid Association·Yaron TomerDavid A Greenberg
Aug 22, 2003·British Journal of Haematology·Hannah CullupPeter G Middleton
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Oct 23, 2003·Endocrine Reviews·Yaron Tomer, Terry F Davies
Jul 14, 2004·Neuroimmunomodulation·Costas PhenekosMichael Papamichail
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·M R VelagaS H S Pearce
Nov 24, 2004·American Journal of Human Genetics·Matthew J SimmondsStephen C L Gough
Mar 3, 2005·The Journal of Clinical Endocrinology and Metabolism·Hitomi HirataniTakashi Akamizu
May 25, 2006·Bioinformatics·Xavier SoléVíctor Moreno
Aug 19, 2006·Human Immunology·Shizhong HanYumin Mao
Oct 28, 2006·Endocrinology·Andrew G GianoukakisTerry J Smith
Apr 9, 2008·Human Immunology·Lorenzo BerettaRaffaella Scorza
Aug 21, 2008·Thyroid : Official Journal of the American Thyroid Association·Andrew G GianoukakisTerry J Smith
Aug 21, 2008·Thyroid : Official Journal of the American Thyroid Association·Vibhavari NaikRaymond S Douglas
Oct 8, 2008·Rheumatology·P HarrisonB P Wordsworth
Mar 11, 2009·Current Eye Research·Katarzyna LackaJan K Lacki
Jun 30, 2009·Human Immunology·Ajda BicekSergej Hojker
Citations
Aug 13, 2013·Endocrine·Liqiong XueHuaidong Song
Nov 21, 2012·Journal of Biomedical Science·Yu-Huei LiuFuu-Jen Tsai
Jan 28, 2014·PloS One·Min-Li ChenZheng-Fu Xie
May 29, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·John H Lazarus
Mar 10, 2011·International Journal of Immunogenetics·T FurutaT Nakashima
Sep 17, 2015·Journal of Molecular Endocrinology·Ni YanJinan Zhang
Nov 19, 2015·Scientific Reports·Kah Hie WongLi Jia Chen
Apr 22, 2016·Immunologic Research·Xiao-Lei HuangJing Wang
Aug 16, 2014·PloS One·Cecília DurãesPaula Soares
Apr 30, 2015·Cytokine·Mercedes MonteleoneKate Schroder
Feb 9, 2017·Canadian Journal of Physiology and Pharmacology·Tong WuFeng-Yuan Sun
Jun 8, 2018·PloS One·Hang SuJiaxiang Cheng
Mar 13, 2014·International Journal of Cancer. Journal International Du Cancer·Cecília DurãesNúria Sala
Jan 1, 2015·Terapevticheskiĭ arkhiv·N S MartirosianV V Nosikov
Jul 22, 2020·Clinical Endocrinology·Yip Han ChinChin Meng Khoo
Jun 1, 2020·Journal of Endocrinological Investigation·P ZhuY Lu
May 6, 2021·Science Progress·Huaguo Wang, Yi Wang
Jun 9, 2014·Ophthalmology·Yu-Huei LiuFuu-Jen Tsai