The association of interleukin-31 polymorphisms with interleukin-31 serum levels and risk of systemic lupus erythematosus

Rheumatology International
Hua-Tuo HuangYe-Sheng Wei

Abstract

Interleukin-31 (IL-31) is the most recently discovered member of the gp130/IL-6 cytokine family which is produced mainly by activated Th2 cells. IL-31 was proved to play a crucial role in autoimmune and inflammatory diseases such as atopic dermatitis, asthma, cutaneous T cell lymphomas, Kawasaki disease and allergic rhinitis. Previous studies have identified that IL-31 could significantly induce the release of proinflammatory cytokines IL-6. Moreover, a large number of studies have shown that IL-6 plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). However, up to date, no study to data was reported on the relationship between IL-31 and SLE. Therefore, in the present study, we investigated the association between IL-31 polymorphisms and its serum levels with the risk of SLE in a Chinese population. We analyzed two single nucleotide polymorphisms of IL-31 gene rs7977932 C/G and rs4758680 G/T in 190 patients with SLE and 250 age- and sex-matched controls, using polymerase chain reaction-single base extension and DNA sequencing methods. Soluble IL-31 (sIL-31) levels were measured by ELISA. From this study, we found that there were significant differences in the genotype and allele frequencies of IL-31...Continue Reading

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Citations

May 24, 2018·Genetic Testing and Molecular Biomarkers·Yongfeng YangHong Bu
Jul 3, 2020·Immunological Investigations·Ning MuZaixing Yang
Jul 10, 2019·Frontiers in Immunology·Bernhard F GibbsUlrike Raap
May 10, 2020·BioMed Research International·Yong-Ling HeXiang Shi
May 2, 2018·Mediators of Inflammation·Eleonora Di SalvoSebastiano Gangemi
Feb 26, 2021·Allergy·Angeliki DatsiJoerg Buddenkotte
Sep 30, 2021·Experimental and Therapeutic Medicine·Chunli RongXiuru Guan

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