The association of liver fat content and serum alanine aminotransferase with bone mineral density in middle-aged and elderly Chinese men and postmenopausal women

Journal of Translational Medicine
Ming-Feng XiaXin Gao

Abstract

Recent studies have linked non-alcoholic fatty liver disease (NAFLD) to a reduced bone mineral density (BMD). We aimed to detect the quantitative association of liver fat content (LFC) and serum alanine aminotransferase (ALT) with BMD in a middle-aged and elderly Chinese population. The lumbar spine, hip and whole body BMDs were measured using dual-energy x-ray absorptiometry (Lunar iDXA, GE Healthcare) in 1659 Chinese (755 men and 1028 postmenopausal women) from Shanghai Changfeng community. Liver fat content was quantified via an ultrasound quantitative method. Multivariate linear regression analyses were carried out to determine the independent association of LFC and serum ALT with BMD and bone metabolic biomarkers. We also attempted to investigate the synergistic association between LFC and ALT as risk factors for bone mineral loss in Chinese. Subjects with higher LFC had significantly lower BMD at all skeletal sites. Univariate correlation analysis showed that both LFC and ALT were inversely associated with BMD at the spine (r = -0.116, P < 0.001 and r = -0.102, P = 0.005), hip (r = -0.095, P = 0.014 and r = -0.075, P = 0.041) and whole body sites (r = -0.134, P < 0.001 and r = -0.164, P < 0.001) in men. After confounders ...Continue Reading

References

Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M J OurslerT C Spelsberg
Jan 1, 1991·Critical Reviews in Clinical Laboratory Sciences·M J Power, P F Fottrell
Jun 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R B MazessN H Bell
Oct 20, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C Cooper
Jan 5, 2002·Journal of the Royal Society of Medicine·Pardeep Grewal, Brian Fitzgerald
Mar 28, 2006·Progress in Biophysics and Molecular Biology·P Lips
Aug 25, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Giovanni TargherGuido Arcaro
Apr 4, 2007·Alimentary Pharmacology & Therapeutics·P Angulo
Jun 15, 2007·Journal of Gastroenterology and Hepatology·Geoffrey C FarrellUNKNOWN Asia-Pacific Working Party on NAFLD
Feb 21, 2008·The Journal of Clinical Endocrinology and Metabolism·Changhai DingGraeme Jones
Feb 29, 2008·Journal of Hepatology·Nimantha Mark Wilfred de Alwis, Christopher Paul Day
Apr 22, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Markus HerrmannMarkus Seibel
Feb 17, 2009·Metabolism: Clinical and Experimental·Ruth M FranklinJill A Kanaley
Jan 26, 2010·Nature Reviews. Endocrinology·Masanobu Kawai, Clifford J Rosen
Jun 24, 2010·The Proceedings of the Nutrition Society·Jeremy F L CobboldSimon D Taylor-Robinson
Feb 5, 2011·Nephron. Clinical Practice·Marlies NoordzijKitty J Jager
May 3, 2011·The Journal of Surgical Research·Yu-Bin ZhangJian-Ting Chen
Aug 26, 2011·The American Journal of Clinical Nutrition·Shilpa N BhupathirajuKatherine L Tucker
Nov 25, 2011·Alimentary Pharmacology & Therapeutics·P E PardeeJ B Schwimmer
Feb 4, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Sombat TreeprasertsukPaul Angulo
Apr 3, 2012·The Journal of Clinical Endocrinology and Metabolism·Mian LiGuang Ning
Oct 18, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Daniel L KollerTatiana Foroud
Jul 3, 2013·Trends in Molecular Medicine·Giovanni MussoFederica Molinaro
May 28, 2014·Experimental Gerontology·Ursula Föger-SamwaldPeter Pietschmann
Feb 14, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Z ChenF D Gilliland

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Citations

Oct 21, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S H AhnS Hong
Oct 24, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·X L DongM S Wong
Oct 21, 2016·Journal of Endocrinological Investigation·S H LeeB Cho
Mar 30, 2017·World Journal of Gastroenterology : WJG·Eleonora PoggiogalleLucia Pacifico
Oct 19, 2020·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Jisun SungHae-Kwan Cheong
Mar 18, 2021·Journal of Magnetic Resonance Imaging : JMRI·Qiang MaZhenchang Wang
Dec 11, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael H LeMindie H Nguyen

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Methods Mentioned

BETA
biopsies

Software Mentioned

SPSS
NIH image
ImageJ

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