The Association of Low Hemoglobin Levels with IgA Nephropathy Progression: A Two-Center Cohort Study of 1,828 Cases.

American Journal of Nephrology
Bin ZhuHong-Yu Chen

Abstract

To investigate the relationship between hemoglobin levels and the progression of IgA nephropathy (IgAN). In a two-center cohort of 1,828 cases with biopsy-proven IgAN, we examined the association of hemoglobin levels with the primary outcome of a composite of all-cause mortality or kidney failure defined as a 40% decline in eGFR, or ESKD (defined as eGFR <15 mL/min/1.73 m2 or need for kidney replacement therapy including hemodialysis, peritoneal dialysis, or kidney transplantation), or the outcome of kidney failure, assessed using Cox and logistic regression models, respectively, with adjustment for confounders. At baseline, mean age, eGFR, and hemoglobin levels were 33.75 ± 11.03 years, 99.70 ± 30.40 mL/min/1.73 m2, and 123.47 ± 18.36 g/L, respectively. During a median of approximately 7-year follow-up, 183 cases reached the composite outcome. After adjustment for demographic and IgAN-specific covariates and treatments, a lower quartile of hemoglobin was nonlinearly associated with an increased risk of the primary outcome or kidney failure in the Cox proportional hazards models (primary outcome: HR for quartile 3 vs. 4, 1.37; 95% CI, 0.83-2.25; HR for quartile 2 vs. 4, 1.18; 95% CI, 0.68-2.07; HR for quartile 1 vs. 4, 1.91; 95...Continue Reading

References

Nov 6, 2007·Journal of the American Society of Nephrology : JASN·Heather N ReichUNKNOWN Toronto Glomerulonephritis Registry
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jul 3, 2009·Kidney International·UNKNOWN Working Group of the International IgA Nephropathy Network and the Renal Pathology SocietyHong Zhang
Jul 3, 2009·Kidney International·UNKNOWN Working Group of the International IgA Nephropathy Network and the Renal Pathology SocietyHong Zhang
Aug 16, 2011·Seminars in Nephrology·Jonathan Barratt, John Feehally
Apr 28, 2012·Journal of the American Society of Nephrology : JASN·Jicheng LvUNKNOWN TESTING Study Group

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.