The Association of Lung Function, Bronchial Hyperresponsiveness, and Exhaled Nitric Oxide Differs Between Atopic and Non-atopic Asthma in Children

Allergy, Asthma & Immunology Research
Eunhee ShimJinho Yu

Abstract

Although many previous studies have attempted to identify differences between atopic asthma (AA) and non-atopic asthma (NAA), they have mainly focused on the difference of each variable of lung function and airway inflammation. The aim of this study was to evaluate relationships between lung function, bronchial hyperresponsiveness (BHR), and the exhaled nitric oxide (eNO) levels in children with AA and NAA. One hundred and thirty six asthmatic children aged 5-15 years and 40 normal controls were recruited. Asthma cases were classified as AA (n=100) or NAA (n=36) from skin prick test results. Lung function, BHR to methacholine and adenosine-5'-monophosphate (AMP), eNO, blood eosinophils, and serum total IgE were measured. The AA and NAA cases shared common features including a reduced small airway function and increased BHR to methacholine. However, children with AA showed higher BHR to AMP and eNO levels than those with NAA. When the relationships among these variables in the AA and NAA cases were evaluated, the AA group showed significant relationships between lung function, BHR to AMP or methacholine and eNO levels. However, the children in the NAA group showed an association between small airway function and BHR to methachol...Continue Reading

References

Jan 19, 1995·The New England Journal of Medicine·F D MartinezW J Morgan
Apr 8, 1999·Thorax·S Chinn
May 20, 1999·Journal of Korean Medical Science·J W SonY Y Kim
Aug 13, 1999·The European Respiratory Journal·G L PiacentiniA L Boner
Nov 26, 1999·The European Respiratory Journal·C GratziouC Roussos
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·M Van Den BergeD S Postma
Jan 31, 2002·American Journal of Respiratory and Critical Care Medicine·Gea De MeerDirkje S Postma
Aug 29, 2006·Lancet·Sabina IlliUNKNOWN Multicentre Allergy Study (MAS) group
Mar 24, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jose A Castro-RodriguezLuis Garcia-Marcos
Feb 5, 2008·Journal of Managed Care Pharmacy : JMCP·Frank L Urbano
May 31, 2008·American Journal of Respiratory and Critical Care Medicine·Graziella TuratoMarina Saetta
Nov 10, 2009·The Journal of Allergy and Clinical Immunology·Anne M FitzpatrickUNKNOWN National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program
Nov 26, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Donald Cockcroft, Beth Davis
Jan 25, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D I SuhY Y Koh
May 19, 2012·Allergy·I AgacheJ C Virchow
Jul 25, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Mitsuru Munakata
Aug 23, 2012·Clinical and Translational Allergy·Chrysanthi L SkevakiNikolaos G Papadopoulos

❮ Previous
Next ❯

Citations

Jan 30, 2016·PloS One·Mohammad Reza RaoufySohrab Hajizadeh
Jan 30, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N TsolakisK Alving
Feb 13, 2018·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Marina LluncorSantiago Quirce
Feb 14, 2018·International Forum of Allergy & Rhinology·Sarah K WiseMark Zacharek
Jan 18, 2020·The European Respiratory Journal·Andrew Menzies-GowChristopher E Brightling

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
lavage

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

© 2022 Meta ULC. All rights reserved