The Association of Maternal Thyroid Autoimmunity During Pregnancy With Child IQ

The Journal of Clinical Endocrinology and Metabolism
Arash DerakhshanRobin P Peeters

Abstract

Thyroperoxidase antibody (TPOAb) positivity is a major risk factor for gestational thyroid dysfunction. During the first 18 to 20 weeks of pregnancy, high concentrations of human chorionic gonadotropin (hCG) stimulate the thyroid to ensure adequate thyroid hormone availability for the developing fetus. However, TPOAb-positive women have an impaired thyroidal response to hCG stimulation. To study the association of maternal TPOAb positivity during pregnancy with child IQ. This study was embedded in two prospective birth cohorts: Generation R (Rotterdam, the Netherlands) and Avon Longitudinal Study of Parents and Children (ALSPAC; United Kingdom). Mother-child pairs with available data on early pregnancy TPOAb (≤18 weeks of gestation) and offspring IQ were included (n = 3637 for Generation R and n = 2396 for ALSPAC). Child IQ at 5 to 10 years of age. In Generation R, TPOAb positivity was associated with a 2.0 ± 0.9-point lower mean child IQ (P = 0.03). Sensitivity analyses showed negative effect estimates already from TPOAb concentrations considerably lower than currently used manufacturer cutoffs. In ALSPAC, neither TPOAb positivity nor TPOAb concentrations below manufacturer cutoffs were associated with child IQ (TPOAb positivi...Continue Reading

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Citations

Feb 26, 2019·Thyroid : Official Journal of the American Thyroid Association·Yong ZhangJianxia Fan
Jun 20, 2019·The Journal of Clinical Endocrinology and Metabolism·Chen ZhangHe-Feng Huang
Oct 17, 2019·JAMA Network Open·Akhgar GhassabianMònica Guxens
Sep 14, 2021·Journal of Endocrinological Investigation·A AmouzegarF Azizi
Jan 10, 2022·The Journal of Clinical Endocrinology and Metabolism·Peixuan LiKun Huang

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