The association of meniscal pathologic changes with cartilage loss in symptomatic knee osteoarthritis

Arthritis and Rheumatism
D J HunterD T Felson

Abstract

To explore the role of meniscal tears and meniscal malposition as risk factors for subsequent cartilage loss in subjects with symptomatic osteoarthritis (OA). Study subjects were patients with symptomatic knee OA from the Boston Osteoarthritis of the Knee Study. Baseline assessments included knee magnetic resonance imaging (MRI) with followup MRI at 15 and 30 months. Cartilage and meniscal damage were scored on MRI in the medial and lateral tibiofemoral joints using the semiquantitative whole-organ magnetic resonance imaging score. Tibiofemoral cartilage was scored on MR images of all 5 plates of each tibiofemoral joint, and the meniscal position was measured using eFilm Workstation software. A proportional odds logistic regression model with generalized estimating equations was used to assess the effect of each predictor (meniscal position factor and meniscal damage as dichotomous predictors in each model) on cartilage loss in each of the 5 plates within a compartment. Models were adjusted for age, body mass index (BMI), tibial width, and sex. We assessed 257 subjects whose mean +/- SD age was 66.6 +/- 9.2 years and BMI was 31.5 +/- 5.7 kg/m2; 42% of subjects were female, and 77% of knees had a Kellgren/Lawrence radiographic s...Continue Reading

References

Jan 1, 1974·Annals of the Rheumatic Diseases·B B SeedhomV Wright
Mar 3, 1998·European Journal of Radiology·K L VerstraeteM Kunnen
Aug 15, 1998·Arthritis and Rheumatism·D T Felson, Y Zhang
Nov 24, 1999·Osteoarthritis and Cartilage·D R GaleD Felson
Feb 7, 2001·The Journal of Bone and Joint Surgery. British Volume·M J McNicholasL S Lohmander
Sep 11, 2003·Annals of Internal Medicine·David T FelsonDaniel Gale
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Feb 20, 2004·Osteoarthritis and Cartilage·C G PeterfyH K Genant

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Citations

Aug 16, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hideki HiraiwaNaoki Ishiguro
Sep 20, 2008·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·S D MasourosA M J Bull
Oct 20, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Henning MadryAndrea Facchini
May 5, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Avi ElbazRonen Debi
Jun 13, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Semih AkkayaFusun Ardic
Oct 15, 2009·Rheumatology International·Kwang Am JungDavid John Hunter
Feb 16, 2013·Wiener medizinische Wochenschrift·Judith Sautner, Claudia Schueller-Weidekamm
Feb 2, 2013·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·David Hunter
Mar 3, 2009·Nature Clinical Practice. Rheumatology·Claire Y J Wenham, Philip G Conaghan
Jan 17, 2013·Nature Reviews. Rheumatology·Ali GuermaziDaichi Hayashi
May 23, 2012·Nature Reviews. Rheumatology·Martin EnglundAli Guermazi
Sep 12, 2008·The New England Journal of Medicine·Martin EnglundDavid T Felson
Jun 28, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Shari Miura LingLuigi Ferrucci
Sep 1, 2007·Current Opinion in Rheumatology·Felix EcksteinDavid Hunter
Apr 3, 2009·Current Opinion in Rheumatology·David J HunterFelix Eckstein
Jan 10, 2012·Current Opinion in Rheumatology·Yubo Sun, David R Mauerhan
Dec 29, 2010·Journal of Biomechanical Engineering·Nathan A NetravaliThomas P Andriacchi
Sep 8, 2012·Annals of the Rheumatic Diseases·Frank W RoemerUNKNOWN MOST study investigators
Aug 14, 2010·Annals of the Rheumatic Diseases·Alison ChangLeena Sharma
Dec 1, 2010·Therapeutic Advances in Musculoskeletal Disease·Deborah M AllenDavid J Hunter
Jan 30, 2010·BMC Musculoskeletal Disorders·Yubo SunHelen E Gruber
Apr 8, 2011·BMC Musculoskeletal Disorders·Ajay M AbrahamFraser Birrell
Feb 26, 2010·Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology : SMARTT·Akinori KanShuji Okinaga
Mar 10, 2009·Arthritis Research & Therapy·Thomas V StablerVirginia Byers Kraus
Jan 10, 2013·Arthritis Research & Therapy·Meina WangDi Chen
Oct 22, 2009·AJR. American Journal of Roentgenology·Klaus M FriedrichRavinder Regatte

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