The association of methylenetetrahydrofolate reductase genotypes with the risk of childhood leukemia in Taiwan

PloS One
Jen-Sheng PeiDa-Tian Bau

Abstract

Acute lymphoblastic leukemia (ALL) is the most prevalent type of pediatric cancer, the causes of which are likely to involve an interaction between genetic and environmental factors. To evaluate the effects of the genotypic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) on childhood ALL risk in Taiwan, two well-known polymorphic genotypes of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed to examine the extent of their associations with childhood ALL susceptibility and to discuss the MTHFR genotypic contribution to childhood ALL risk among different populations. In total, 266 patients with childhood ALL and an equal number of non-cancer controls recruited were genotyped utilizing PCR-RFLP methodology. The MTHFR C677T genotype, but not the A1298C, was differently distributed between childhood ALL and control groups. The CT and TT of MTHFR C677T genotypes were significantly more frequently found in controls than in childhood ALL patients (odds ratios=0.60 and 0.48, 95% confidence intervals=0.42-0.87 and 0.24-0.97, respectively). As for gender, the boys carrying the MTHFR C677T CT or TT genotype conferred a lower odds ratio of 0.51 (95% confidence interval=0.32-0.81, P=0.0113) for childhood ALL. As for...Continue Reading

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Citations

Nov 4, 2015·European Journal of Pharmacology·Ewelina KałużnaDanuta Januszkiewicz-Lewandowska
Feb 5, 2016·Drug Metabolism and Personalized Therapy·Ossyneidee Gutiérrez-ÁlvarezClaudia E Bailón-Soto
Feb 20, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Rim Frikha
Oct 17, 2020·Journal of Pediatric Hematology/oncology·Rim FrikhaTarek Rebai

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Methods Mentioned

BETA
xenografts
genotyping
PCR
electrophoresis

Software Mentioned

SPSS
SAS

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