PMID: 9434791Jan 22, 1998Paper

The association of MHC with autoimmune diseases: understanding the pathogenesis of autoimmune diabetes

Clinical Immunology and Immunopathology
W M Ridgway, C G Fathman

Abstract

The current paradigm of MHC and disease association is efficient binding of autoantigens by disease-associated MHC molecules leading to a T cell-mediated immune response and resultant autoimmune sequelae. Data presented here offer a different model for this association of MHC with autoimmune diabetes. This new explanation suggests that the association of MHC with autoimmunity results from "altered" thymic selection in which high-affinity self-reactive (potentially autoreactive) T cells escape negative selection. This model offers an explanation for the requirement of homozygous MHC class II expression in NOD mice (and in man) in susceptibility to IDDM.

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Jan 13, 2000·Current Opinion in Immunology·W M Ridgway, C G Fathman
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