The association of mitochondrial aldehyde dehydrogenase gene (ALDH2) polymorphism with susceptibility to late-onset Alzheimer's disease in Chinese

Journal of the Neurological Sciences
Binbin WangXu Ma

Abstract

A functional polymorphism of mitochondrial aldehyde dehydrogenase gene (ALDH2 1/2 polymorphism) can influence the accumulation of acetaldehyde which may have a role in Alzheimer's disease (AD), and is widely prevalent among Mongoloids. Therefore ALDH2 1/2 polymorphism may represent a good candidate for genetic risk factors for AD, especially in East Asian. A case-control study from Japan found that ALDH2*2 was associated with late-onset AD (LOAD), interacting synergistically with the presence of the apolipoprotein E allele 4 (APOE epsilon4). But the subsequent studies in Koreans didn't find the similar result. To determine whether the ALDH2 gene 1/2 polymorphism contributes to the risk for LOAD in Chinese, we have investigated 188 sporadic LOAD patients and 223 healthy controls from Chinese. A significantly increased risk of AD in the carriers of ALDH2*2 allele (OR=3.11, 95% CI 2.06-4.69, P<0.001) was observed. After stratifying by APOE epsilon4 status, increased LOAD risks associated with the ALDH2 2 allele carriers only in the APOE epsilon4 non-carriers (chi2=31.79, df=1, P<0.001) and with the 2-allele in either groups (chi2=6.64 df=1, P=0.0099 and chi2=37.38, df=1, P<0.001) were seen. These results suggested that the ALDH2 g...Continue Reading

References

Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L C HsuA Yoshida
Mar 1, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·C PowerJ C McArthur
Dec 11, 1999·Archives of Neurology·W R Markesbery
Oct 31, 2001·Neuron·R E Tanzi, L Bertram
May 6, 2004·Annals of the New York Academy of Sciences·Shigeo OhtaHiroshi Shimokata
Oct 27, 2005·International Journal of Geriatric Psychiatry·Ii-Seon ShinJin-Sang Yoon

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Citations

Jul 10, 2008·Expert Opinion on Drug Metabolism & Toxicology·Satori A MarchittiVasilis Vasiliou
Oct 9, 2014·Annual Review of Pharmacology and Toxicology·Eric R GrossDaria Mochly-Rosen
Oct 8, 2016·Environmental Health and Preventive Medicine·Akiko MatsumotoVasilis Vasiliou
Feb 3, 2016·Nihon eiseigaku zasshi. Japanese journal of hygiene·Akiko Matsumoto
Jul 17, 2009·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Koho Miyoshi
Oct 21, 2010·Alcoholism, Clinical and Experimental Research·Yu YanChun-Fu Wu
Mar 20, 2010·Journal of Enzyme Inhibition and Medicinal Chemistry·Bibiana M GayAlcindo A Dos Santos
Jan 3, 2014·Physiological Reviews·Che-Hong ChenDaria Mochly-Rosen
Jul 10, 2019·Alcoholism, Clinical and Experimental Research·Ryan N SerioLorraine J Gudas
Jun 17, 2014·Alcoholism, Clinical and Experimental Research·Akiko MatsumotoMasayoshi Ichiba
Apr 3, 2015·Physiological Reviews·Yuri L DorokhovTatiana V Komarova
Feb 2, 2018·Nihon eiseigaku zasshi. Japanese journal of hygiene·Akiko Matsumoto
Oct 31, 2014·Proteins·Javier A Belmont-DíazJosé S Rodríguez-Zavala
Jun 10, 2020·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Jun NakamuraScott J Bultman
Apr 26, 2011·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Pan-Pan HaoYun Zhang
Dec 10, 2019·Communications Biology·Li AiZhiqian Tong
Nov 8, 2019·Expert Opinion on Therapeutic Targets·Mitsuru KimuraSusumu Higuchi
Jan 12, 2020·Communications Biology·Li AiZhiqian Tong
May 7, 2021·Acta Biochimica Et Biophysica Sinica·Ying YangWei Ge
Feb 8, 2011·Chemico-biological Interactions·Mahul Chakraborty, James D Fry

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