The association of multiple sclerosis and Hodgkin's disease: the role of Epstein-Barr virus infection

Multiple Sclerosis : Clinical and Laboratory Research
Mario HabekSanja Hajnsek

Abstract

The aetiology of multiple sclerosis (MS) is still an unresolved question. Several recently reported studies are implicating Epstein-Barr virus (EBV) as one of the key players in MS pathogenesis. We present a 21-year-old male patient with a history of EBV-related infectious mononucleosis in puberty and Hodgkin's disease two years previously treated with irradiation and chemotherapy. The patient presented with spastic paraparesis that resolved promptly on corticosteroid treatment. There were no signs of Hodgkin's disease relapse. In the next three years he had three more bouts of the disease and he was diagnosed with relapse-remitting MS. There is evidence of EBV involvement in MS pathogenesis; the association of MS with EBV-related infectious mononucleosis and Hodgkin's disease being just one of them. Although there are many unanswered questions, it is clear that without EBV seropositivity MS in adults is extremely rare.

References

May 1, 1976·Acta Neurologica Scandinavica·J F Kurtzke, H Hamtoft
Jan 1, 1992·The Journal of Emergency Medicine·K T BellianR F Edlich
Feb 1, 1970·American Journal of Epidemiology·G R Newell
Oct 6, 2000·Epidemiology·A Ascherio, M Munch
Mar 16, 2004·Acta Neurologica Scandinavica·S HaahrP Höllsberg
Apr 22, 2004·JAMA : the Journal of the American Medical Association·Suad AlotaibiBrenda Banwell
May 20, 2004·Journal of the National Cancer Institute·Henrik HjalgrimMads Melbye
Jun 5, 2004·Clinical Neurology and Neurosurgery·A D Sadovnick
Apr 7, 2005·Journal of the National Cancer Institute·Ola LandgrenLynn R Goldin
Aug 24, 2006·Reviews in Medical Virology·Sven Haahr, Per Höllsberg
Nov 7, 2006·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Alexandar Tzankov, Stephan Dirnhofer
Jan 11, 2007·Archives of Neurology·Trine Rasmussen NielsenHenrik Hjalgrim

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Citations

Jan 1, 2011·BMJ Case Reports·Javier MunozPhilip Kuriakose
Jul 12, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Mario HabekDavid Ozretić
Aug 21, 2013·European Journal of Medical Genetics·Carsten HolzmannPeter Meyer
Apr 11, 2009·Current Opinion in Neurology·Marco SalvettiFrancesca Aloisi
May 7, 2009·Current Opinion in Neurology

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