The association of NAT1 polymorphisms and colorectal carcinoma risk: evidence from 20,000 subjects.

Molecular Biology Reports
Jie CaiZu Hu Huang

Abstract

Published data on the association between N-acetyltransferase 1 (NAT1) gene polymorphisms and colorectal carcinoma (CRC) susceptivity are inconclusive. To derive a more precise estimation of the association, we conducted this meta-analysis. Data were collected from electronic databases: PubMed, EMBASE, with the last report up to May 2010. The odds ratio (OR) and corresponding 95% confidence intervals (CIs) were used to assess the strength of the association. A total of 20 individual studies including 8,219 cases and 11,498 controls based on the search criteria were involved. Meta-analysis was performed for slow versus rapid acetylation genotypes of NAT1. We found no association between NAT1 polymorphisms and CRC in overall population (OR = 0.96, 95% CI = 0.88-1.05 P = 0.05 for heterogeneity) without significant publication bias present. In subgroup analyses, similar results were found in different ethnicities, source of controls, genotyping methods and adjustment. Current meta-analysis suggests that lack of association between the NAT1 polymorphisms and individual risk to CRC.

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C A SmithC R Wolf
Sep 13, 1996·Science·N Risch, K Merikangas
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Dec 10, 1999·International Journal of Cancer. Journal International Du Cancer·T KatohD A Bell
Jun 26, 2001·Journal of Gastroenterology and Hepatology·W J ButlerI C Roberts-Thomson
Oct 16, 2001·Nature Genetics·J P IoannidisD G Contopoulos-Ioannidis
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Teresa NoratElio Riboli
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jun 20, 2003·Cancer Causes & Control : CCC·Olga L van der HelPetra H M Peeters
Jun 1, 1955·Annals of Human Genetics·B WOOLF
Jun 17, 2004·Environmental and Molecular Mutagenesis·Amanda J Cross, Rashmi Sinha
Oct 22, 2004·American Journal of Epidemiology·Martha L SlatteryS Neuhausen
Nov 24, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A J SascoK Straif
Jul 12, 2005·Pharmacogenetics and Genomics·Stefano LandiUNKNOWN Bellvitge Colorectal Cancer Study Group
Oct 6, 2005·Journal of the National Cancer Institute·Brenda K EdwardsLinda W Pickle
Jan 26, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Carmen LillaJenny Chang-Claude
Mar 4, 2008·Gastroenterology Clinics of North America·Tusar K Desai, Donald Barkel
Mar 11, 2009·Diseases of the Colon and Rectum·Chih-Ching YehLing-Ling Hsieh
Jun 25, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ute NöthlingsLoïc Le Marchand
Oct 13, 2010·American Journal of Epidemiology·Sean P ClearyPatricia Harper

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Citations

Apr 10, 2013·The Journal of International Medical Research·Ke WuYiping Lu
Sep 18, 2018·Pharmacogenetics and Genomics·David W HeinSotiria Boukouvala
May 3, 2016·International Journal of Molecular Sciences·Rabeah A Al-TemaimiFahd Al-Mulla
Dec 16, 2020·Comprehensive Reviews in Food Science and Food Safety·Xiaoqian ChenYu Zhang

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