The association of non-alcoholic fatty liver disease with thyroid peroxidase and thyroglobulin antibody: A new insight from SPECT-China study

Autoimmunity
Yi ChenYingli Lu

Abstract

Non-alcoholic fatty liver disease (NAFLD) has been studied with inflammation and immune, but the link with thyroid autoimmunity is unreported. This study aimed to explore the direct association of NAFLD with thyroid autoimmune disease (AITD) among participants with normal thyroid stimulating hormone (TSH) levels. The data were obtained from a cross-sectional study (SPECT-China). A total of 7982 participants were enrolled. Participants underwent several checkups including peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), thyroid, and liver ultrasonography (US). The prevalence of NAFLD was higher in TPOAb and/or TgAb positive [TPO/TgAb (+)] group and TPOAb and/or TgAb together with US positive [TPO/TgAb (+) and US (+)] group for both genders. After full adjustment, binary logistic analysis showed the presence of NAFLD was positively associated with the serum level of TPOAb in men (p < .001) and TgAb in women (p = .001). Both TPO/TgAb (+) and TPO/TgAb (+) and US (+) were associated with an increased risk of NAFLD in both genders [TPO/TgAb (+): odds ratio (OR) 1.474, 95% confidence interval (CI) 1.102, 1.970 in men and OR 1.308, 95%CI 1.061, 1.612 in women; TPO/TgAb (+) and US (+): OR 1.796, 95%CI 1.143, 2.820 in men and ...Continue Reading

References

Sep 1, 1997·Clinical Immunology and Immunopathology·D L JacobsonN M Graham
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey D BrowningHelen H Hobbs
Sep 6, 2005·Journal of Hepatology·Ayako SuzukiPaul Angulo
Sep 27, 2005·Lancet·K George M M AlbertiUNKNOWN IDF Epidemiology Task Force Consensus Group
Jul 8, 2008·Autoimmunity Reviews·Ana LleoMauro Podda
Dec 21, 2011·Digestive Diseases and Sciences·Mangesh R PagadalaArthur J McCullough
Mar 6, 2012·Autoimmunity Reviews·Scott M Hayter, Matthew C Cook
Mar 20, 2012·Journal of Hepatology·Goh Eun ChungHyo-Suk Lee
Apr 21, 2012·European Journal of Endocrinology·Grigoris EffraimidisWilmar M Wiersinga
May 12, 2012·Thyroid : Official Journal of the American Thyroid Association·Till IttermannHenry Völzke
Mar 20, 2013·Nature Reviews. Gastroenterology & Hepatology·Quentin M AnsteeChristopher P Day
Jan 1, 2012·Hormones : International Journal of Endocrinology and Metabolism·Giulia Cogni, Luca Chiovato
Dec 11, 2013·Thyroid : Official Journal of the American Thyroid Association·Yun Mi ChoiWon Bae Kim
Jun 14, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·James FungUNKNOWN Hong Kong Liver Health Census Study Group
Oct 11, 2014·TheScientificWorldJournal·Yong Lin Liu, Xiaobo Cai
Feb 20, 2015·Expert Review of Gastroenterology & Hepatology·Stefano BallestriAmedeo Lonardo
Mar 10, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hae-Ki MinArun J Sanyal
Dec 5, 2015·Expert Review of Gastroenterology & Hepatology·Salvatore SuttiEmanuele Albano
Dec 18, 2015·The Journal of Clinical Endocrinology and Metabolism·Fernando BrilKenneth Cusi
Feb 5, 2016·Digestive Diseases and Sciences·Marco ArreseAriel E Feldstein
Mar 24, 2016·The Journal of Clinical Endocrinology and Metabolism·Ningjian WangYingli Lu
Jun 9, 2016·The Journal of Clinical Endocrinology and Metabolism·Arjola BanoRobin P Peeters
Aug 30, 2016·International Journal of Environmental Research and Public Health·Giovanna MuscogiuriGiovanni Vitale
Nov 22, 2016·Journal of Neuroscience Research·Lisa C Golden, Rhonda Voskuhl
Dec 27, 2016·Autoimmunity·Naoya InoueYoshinori Iwatani
Jun 1, 2017·Thyroid : Official Journal of the American Thyroid Association·Yi ChenYingli Lu
Aug 22, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Donghee KimAijaz Ahmed

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Citations

Feb 11, 2020·Frontiers in Endocrinology·Yunju TangXuemin Shen
Dec 11, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael H LeMindie H Nguyen

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