The association of obesity with sex hormone-binding globulin is stronger than the association with ageing--implications for the interpretation of total testosterone measurements

Clinical Endocrinology
Lori A CooperAlvin M Matsumoto

Abstract

Total testosterone concentrations are influenced by sex hormone-binding globulin (SHBG) concentrations, which are decreased by obesity and increased with ageing. Therefore, we sought to understand and compare the associations of ageing and obesity with SHBG. We performed a retrospective, cross-sectional analysis of the associations of obesity and age on SHBG and testosterone measurements in men being evaluated for hypogonadism. A total of 3671 men who underwent laboratory testing for testosterone deficiency from the Veterans Administration Puget Sound Health Care System from 1997 through 2007 was included. Univariate and multivariate linear regression modelling of the associations between age and body mass index (BMI) and SHBG was performed. Obesity was associated with a significantly lower SHBG [β = -1·26 (95% CI -1·14, -1·38) nmol/l] per unit increase in BMI. In contrast, ageing was associated with a significantly increased SHBG [β = 0·46 (95% CI 0·39, 0·53) nmol/l per year] (P < 0·001 for both effects). The association of obesity with lower SHBG was two to three times larger than the association of ageing with increased SHBG in both univariate and multivariate modelling. On average, obese men (BMI >30 kg/m(2)) had significan...Continue Reading

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Citations

Nov 30, 2018·Clinical Chemistry·Abhilasha Singh, Adrian Sandra Dobs
Apr 20, 2019·International Journal of Impotence Research·Biswas AnupamShah Kejal
Aug 9, 2020·The Journal of International Medical Research·Zhongbao ChenYuanzhong Zhou
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Aug 3, 2019·Journal of Clinical Medicine·Daniel Castellano-CastilloJosé C Fernandez-Garcia
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Jan 27, 2021·Journal of Personalized Medicine·Olga I KiselevaElena A Ponomarenko
Dec 10, 2020·Geburtshilfe und Frauenheilkunde·Heinz Kölbl, Thomas Bartl
Aug 17, 2020·The Journal of Nutritional Biochemistry·Cristina Saez-LopezDavid M Selva
Apr 18, 2021·European Journal of Applied Physiology·Richard S MetcalfeSamuel T Orange
Jun 11, 2021·Journal of Complementary & Integrative Medicine·Sahar A El-MasryMahmoud A S Afify
Aug 22, 2020·Journal of the American Academy of Dermatology·Ellie ChoiNisha Suyien Chandran
Jul 7, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Lucy J GoudswaardNicholas J Timpson

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