The association of obstructive sleep apnea (OSA) and nocturnal hypoxemia with the development of abnormal HbA1c in a population cohort of men without diabetes

Diabetes Research and Clinical Practice
Sarah L AppletonRobert J Adams

Abstract

To examine the relationship between indices of undiagnosed OSA and the development of abnormal glycaemic control in community-dwelling men free of diabetes. The Men, Androgens, Inflammation, Lifestyle, Environment, and Stress (MAILES) Study is a population-based cohort study in Adelaide, South Australia. Clinic visits at baseline (2002-06) and follow-up (2007-10) identified abnormal glycaemic metabolism [HbA1c 6.0 to <6.5% (42 to <48mmol/mol)] in men without diabetes. At follow-up (2010-11), n=837 underwent assessment of OSA by full in-home unattended polysomnography (Embletta X100). Development of abnormal glycaemic metabolism over 4-6 years (n=103 "incident" cases, 17.0%) showed adjusted associations [odds ratio (95% CI)] with the 1st [1.7 (0.8-3.8)], 2nd [2.4 (1.1-4.9)], and 3rd [2.3 (1.1-4.8)] quartiles of mean oxygen saturation (SaO2) compared to the highest quartile. Prevalent abnormal glycaemic metabolism (n=140, 20.8%) was independently associated with the third and fourth quartiles of percentage of sleep time with oxygen saturation <90% and lowest quartile of mean SaO2. Linear regression analysis showed a significant reduction in HbA1c [unstandardized B, 95% CI: -0.02 (-0.04, -0.002), p=0.034] per percentage point incr...Continue Reading

References

Mar 5, 2002·American Journal of Respiratory and Critical Care Medicine·Mary S M IpKaren S L Lam
Jul 25, 2003·The Journal of Physiology·Vsevolod Y PolotskyChristopher P O'Donnell
Sep 9, 2004·American Journal of Epidemiology·Naresh M PunjabiUNKNOWN Sleep Heart Health Study Investigators
Apr 20, 2007·Sleep Medicine Reviews·Kristen L KnutsonEve Van Cauter
Jan 11, 2008·The European Respiratory Journal·J Theorell-HaglöwE Lindberg
Nov 18, 2008·American Journal of Respiratory and Critical Care Medicine·Naresh M Punjabi, Brock A Beamer
Jul 2, 2009·The European Respiratory Journal·P LévyJ Eckel
Dec 19, 2009·American Journal of Respiratory and Critical Care Medicine·Renee S AronsohnEsra Tasali
Mar 5, 2010·The New England Journal of Medicine·Elizabeth SelvinFrederick L Brancati
Mar 13, 2010·Atherosclerosis·Luciano F DragerGeraldo Lorenzi-Filho
May 28, 2010·The New England Journal of Medicine·Giuseppe LippiGiovanni Targher
Jul 30, 2011·Obesity·Luciano F DragerVsevolod Y Polotsky
May 7, 2013·Sleep Medicine Reviews·Tetyana KendzerskaGeorge Tomlinson
Jun 21, 2013·International Journal of Epidemiology·Janet F GrantGary A Wittert
Apr 4, 2014·The European Respiratory Journal·Brian D KentUNKNOWN European Sleep Apnoea Database collaborators
Oct 9, 2014·American Journal of Respiratory and Critical Care Medicine·Babak MokhlesiPaul E Peppard
Feb 16, 2015·The Lancet. Respiratory Medicine·R HeinzerJ Haba-Rubio

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Citations

Feb 6, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Camilla M HoyosSanjay R Patel
Feb 27, 2019·Sleep & Breathing = Schlaf & Atmung·Asuka TakabayashiTakeshi Tanigawa
Aug 22, 2018·Frontiers in Endocrinology·Sarah N Framnes, Deanna M Arble
Jun 22, 2021·Sleep Medicine·R Nisha Aurora, Naresh M Punjabi

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