The association of PASI scores with CRH-R1 expression in patients with psoriasis

Archives of Dermatological Research
Bengü Cevirgen CemilMurat Alper

Abstract

Stress is a well-known triggering factor along with genetic predisposition on the onset and during the course of psoriasis by altering the cellular constituents of the immune system. In the skin, there is a local hypothalamic-pituitary-adrenal (HPA) axis which is the equivalent of the central HPA axis. Corticotropin-releasing hormone (CRH) is a major regulator of the HPA axis in response to stress. This study was planned to show the role of CRH receptor type 1 (CRH-R1) in pathogenesis of psoriasis, the relation with the severity of psoriasis, and interpersonal variance in skin biopsy specimens of the psoriasis patient. Study involved 46 patients with psoriasis and 20 healthy control subjects who were older than 18 years. The clinical sign and PASI scores of psoriasis patients were recorded. Immunohistochemically, expression of CRH-R1 was investigated in psoriatic lesions and control group skin. A statistically significant increase of the expression of CRH-R1 was found in the skin biopsies of psoriasis patients compared with the control group patients. In patients with psoriasis, there was a positive correlation between the expressions of CRH-R1 and PASI scores (p = 0.001, r = +0.572). In addition, a statistically significant in...Continue Reading

References

Jan 1, 1978·Dermatologica·T Fredriksson, U Pettersson
Mar 4, 1992·JAMA : the Journal of the American Medical Association·G P Chrousos, P W Gold
Nov 1, 1984·The Journal of Clinical Endocrinology and Metabolism·T SudaK Shizume
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R ChenW W Vale
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·T KishimotoM G Rosenfeld
Nov 26, 1999·The Journal of Investigative Dermatology·J L ArbiserJ A Majzoub
Apr 25, 2000·In Vitro Cellular & Developmental Biology. Animal·A T SlominskiJ Wortsman
May 19, 2000·Annals of the New York Academy of Sciences·A T SlominskiR Paus
May 19, 2000·Annals of the New York Academy of Sciences·M H Perrin, W W Vale
Feb 24, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·H Devrimci-OzguvenA Boyvat
Mar 16, 2001·In Vitro Cellular & Developmental Biology. Animal·M E QuevedoJ Wortsman
Aug 21, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M KonoR Y Osamura
Feb 28, 2002·Life Sciences·Blazej ZbytekJolanta Mysliwska
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tracy L BaleKuo-Fen Lee
Nov 8, 2003·Endocrinology·Andrzej SlominskiJacobo Wortsman
Mar 25, 2005·The British Journal of Dermatology·B ZbytekA T Slominski
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jing CaoTheoharis C Theoharides
Feb 17, 2006·Experimental Dermatology·Marina O'KaneBrian Kirby
Jul 18, 2006·The Journal of Investigative Dermatology·Petra C ArckRalf Paus
Mar 3, 2007·The Journal of Investigative Dermatology·Michael TagenTheoharis C Theoharides
Jun 30, 2009·Medical Hypotheses·Chunlei ZhouChunyang Li

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Citations

Jul 3, 2016·Reviews in Endocrine & Metabolic Disorders·Alex Alexopoulos, George P Chrousos
Oct 13, 2017·International Journal of Molecular Sciences·Tzu-Kai LinJuan Luis Santiago
Aug 14, 2013·Endocrine Reviews·Andrzej T SlominskiJean Rivier
May 8, 2018·International Journal of Dermatology·Laurie Rousset, Bruno Halioua
Feb 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaoxu WangGuangzhong Zhang
Jul 14, 2021·The British Journal of Dermatology·K NavrazhinaJ G Krueger

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